Abstract
Polyphenols are composed of a wide variety of molecules that are classified into several categories, according to their chemical type such as phenolic acids, flavonoids, stilbenes, and lignans. Many studies have proven the beneficial effects of flavonoids in atherosclerosis progression and cardiovascular disease. Dietary flavonoids reduce oxidative stress and exert anti-inflammatory actions. Moreover, flavonoids have the ability to avoid the thrombus formation, improve endothelial function, modify lipid levels and regulate glucose metabolism. In the context of this evidence in this review article we summarize the so far acquired knowledge of the most important mechanisms of action of flavonoids in atherosclerosis progression.
Keywords: Antioxidants, atheroscierosis, cardiovascular disease, flavonoids, inflammation.
Current Medicinal Chemistry
Title:Flavonoids in Atherosclerosis: An Overview of Their Mechanisms of Action
Volume: 20 Issue: 21
Author(s): G. Siasos, D. Tousoulis, V. Tsigkou, E. Kokkou, E. Oikonomou, M. Vavuranakis, E.K. Basdra, A.G. Papavassiliou and C. Stefanadis
Affiliation:
Keywords: Antioxidants, atheroscierosis, cardiovascular disease, flavonoids, inflammation.
Abstract: Polyphenols are composed of a wide variety of molecules that are classified into several categories, according to their chemical type such as phenolic acids, flavonoids, stilbenes, and lignans. Many studies have proven the beneficial effects of flavonoids in atherosclerosis progression and cardiovascular disease. Dietary flavonoids reduce oxidative stress and exert anti-inflammatory actions. Moreover, flavonoids have the ability to avoid the thrombus formation, improve endothelial function, modify lipid levels and regulate glucose metabolism. In the context of this evidence in this review article we summarize the so far acquired knowledge of the most important mechanisms of action of flavonoids in atherosclerosis progression.
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Cite this article as:
Siasos G., Tousoulis D., Tsigkou V., Kokkou E., Oikonomou E., Vavuranakis M., Basdra E.K., Papavassiliou A.G. and Stefanadis C., Flavonoids in Atherosclerosis: An Overview of Their Mechanisms of Action, Current Medicinal Chemistry 2013; 20 (21) . https://dx.doi.org/10.2174/0929867311320210003
DOI https://dx.doi.org/10.2174/0929867311320210003 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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