Enzyme-catalyzed Synthesis and Degradation of Biopolymers

Title: Enzyme-catalyzed Synthesis and Degradation of Biopolymers

Volume: 6 Issue: 1

Author(s): Tomohiro Hiraishi and Seiichi Taguchi

Affiliation:

Keywords: Biopolymer, polyhydroxyalkanoate (PHA), PHA synthase, enzyme evolution, PHB depolymerase, lipase

Abstract: The synthesis and degradation of biopolymers are cardinal reactions that take place to maintain homeostasis in biosystems. Fundamental biological reactions can be reproduced in vitro by means of enzyme-mediated processes. Recently, bioprocesses have been extensively adopted to synthesize representative biopolymers, including aliphatic polyesters, e.g., polyhydroxyalkanoate (PHA). In particular, the protein engineering of enzymes involved in PHA synthesis has made a great impact on the tailor-made synthesis of polymer materials with high performance. Biopolymers can also be synthesized in vitro by enzyme-catalyzed polymerization using synthetic enzymes and depolymerase-mediated reverse reactions. We will describe these advanced topics from the viewpoint of the boundary field between chemistry and biotechnology.

Cite this article as:

Hiraishi Tomohiro and Taguchi Seiichi, Enzyme-catalyzed Synthesis and Degradation of Biopolymers, Mini-Reviews in Organic Chemistry 2009; 6 (1) . https://dx.doi.org/10.2174/157019309787316139