<![CDATA[Varicocele]]> https://www.eurekaselect.com RSS Feed for Disease Wise Article | BenthamScience EurekaSelect (+http://eurekaselect.com) Fri, 29 Mar 2024 14:33:59 +0000 <![CDATA[Varicocele]]> https://www.eurekaselect.com https://www.eurekaselect.com <![CDATA[Therapeutic Effects of Micronutrient Supplements on Sperm Parameters: Fact or Fiction?]]>https://www.eurekaselect.comarticle/105846Background: Despite the limited evidence about the effect of micronutrient supplementation on the semen quality, many micronutrient supplements have been used to improve male fertility. Approximately, 40%- 50% of male infertility cases in general and up to 80% in men with idiopathic infertility cases are caused by oxidative stress and decreased level of seminal total antioxidant capacity.

Objective: To investigate the beneficial effects of micronutrient supplementation on sperm concentration, motility and morphology.

Methods: A PubMed, Google Scholar, Embase data, Web of Science and Cochrane Library database extensive research of the randomized controlled studies utilizing micronutrient vitamins and supplements was performed.

Results: The existent international literature is rather heterogeneous and a definitive is difficult to be drawn. Several micronutrients have beneficial effects on sperm parameters. Rational use of micronutrients might be helpful for infertile patients.

Conclusion: Further randomized, controlled clinical trials are required to elucidate the efficacy and safety of micronutrients and propose proper protocols for their use. A well-rounded, balanced diet is more preferable than the widespread use of micronutrient supplements beyond the recommended doses. Future studies should concern the pregnancy rate as a primary outcome in their designs. Further research should be done to determine the appropriate antioxidant compounds, the duration of the treatment, as well as a certain dose of antioxidants in clinical practices. The pre-treatment evaluation of the seminal oxidative status is also an important parameter to proceed with micronutrient supplementation without the risk of reductive stress. Under these conditions, supplements could support the quality of sperm and help to alleviate male infertility.

]]>
<![CDATA[Symptoms in Dilating Venous Disease]]>https://www.eurekaselect.comarticle/105168 <![CDATA[An Evidence-Based Review of Off-Label Uses of Polidocanol]]>https://www.eurekaselect.comarticle/88767

Objective: Lack of an appropriate comprehensive review for off-label uses of this medication troubles physicians about making evidence-based decisions on prescribing it for its various outstanding off-label uses. This article attempts to provide physicians with the latest information concerning successful and unsuccessful use of polidocanol as an alternative treatment for esophageal and gastric varices, tendinopathy and epicondylitis, vascular malformations, varicocele, hydrocele and spermatocele, aneurysmal bone cysts, itching, management of gastrointestinal bleeding, simple renal cysts, reducing the incidence and severity of radio-induced dermatitis and hemorrhoids.

Method: The two databases of MEDLINE and Cochrane Library were searched for all human English studies, published in January 2006 to November 2017, which contained the keyword of “polidocanol” or its alternative MeSH terms.

Results: Our search identified a total number of 597 articles. Those articles that were only discussing the approved uses of polidocanol were excluded and the remaining 116 articles were reviewed. Eleven major and 30 minor off-label uses were found within included studies.

Conclusion: Numerous successful administrations of this drug in a variety of clinical conditions lead to promising perspectives toward it. Sclerotherapy with polidocanol as a minimal-invasive method (having similar outcomes like the prevalent surgeries) may reduce the rate of complications. Furthermore, for determining the most appropriate method and dosage, randomized clinical trials are needed, confirming and providing more clear instructions for different conditions.]]> <![CDATA[Redox Regulation of Fertility in Aging Male and the Role of Antioxidants: A Savior or Stressor]]>https://www.eurekaselect.comarticle/79095 <![CDATA[Unravelling the Power of Omics for the Infertile Aging Male]]>https://www.eurekaselect.comarticle/79067

We have thus used an omics approach to identify differentially expressed proteins and genes from spermatozoa and seminal plasma samples across several conditions affecting adult male fertility. Our search resulted in 400 differentially expressed proteins in seminal plasma and 409 differentially expressed proteins in spermatozoa as well as, almost 6,000 differentially expressed spermatozoa mRNAs. We have functionally analyzed these proteins and genes to understand and discuss how biological processes and signaling pathways associated with aging might affect male fertility.

Sperm and seminal fluid proteins from infertile males display significant alterations in i) processes previously implicated in the aging phenomena, such as mitochondrial dysfunction, DNA instability, oxidative stress, protein misfolding and intracellular mistrafficking, and ii) processes specifically involved in reproductive phenomena, such as sperm-egg recognition/acrosome reaction, embryo and morula development, blastocyst implantation and DNA methylation involved in embryo development. These proteins display a widespread distribution and seem to be significantly influenced by deleteriously lifestyle choices. Conventional assays to assess male fertility are inadequate to comprehensively reveal the broad-spectrum of alterations at the transcriptional and translational levels afflicting the infertile aging male. In turn, proteomics and transcriptomics are suitable options for addressing these key issues that may explain many poorly understood fertility-associated phenomena resulting from the aging process.]]> <![CDATA[Penile and Testicular Measurements in Male Neonates and Infants: Single Center Egyptian Study]]>https://www.eurekaselect.comarticle/85733

Objective: The aim of this prospective study was to establish normal reference values for stretched penile length, penile circumference and testicular volume for Egyptian newborn and infants.

Subjects and Methods: This observational cross-sectional study included 1850 healthy male full term newborn and infants applied for routine check-up, aged 0 -24 months, the newborn and infants were recruited from Tanta University Hospital in the period from July 2015 to January 2017. Penile length, penile circumference, testicular volume, weight, length and occipito-frontal circumference were measured.

Results: The studied infants were divided into five groups. Group I: 1-4 weeks, the mean penile length was 3.51 ± 0.49 cm, penile circumference was 3.95 ± 0.48 cm, and testicular size was (right 1.81 ± 0.44 cm and left 1.67 ± 0.47 cm). Group II: > 1-6 months age, the mean penile length was 3.99 ± 0.46 cm, penile circumference was 4.10 ± 0.38 cm, and testicular size was (right 2.10 ± 0.33 cm and left 2.04 ± 0.27 cm). Group III: >6-12 months age, the mean penile length was 4.45 ± 0.48 cm, penile circumference was 4.21 ± 0.33 cm, and testicular size was (right 2.13 ± 0.33 cm and left 2.06 ± 0.28 cm). Group IV: >12-18 months age, the mean penile length was 4.55 ± 0.54 cm, penile circumference was 4.28 ± 0.32 cm, and testicular size was (right 2.12 ± 0.33 cm and left 2.09 ± 0.32 cm). Group V: >18-24 months age, the mean penile length was 4.89 ± 0.63 cm, penile circumference was 4.45 ± 0.33 cm, and testicular size was (right 2.28 ± 0.45 cm and left 2.25 ± 0.45 cm). There were significant positive correlations between penile length, penile circumference, left and right testicular volumes with each other and also with all other anthropometric measures including: weight, height and head circumference.

Conclusion and Recommendation: The age-related values of penile and testicular measurements must be known to be able to determine the abnormal sizes and to monitor treatment of underlying diseases. Our study is a step to achieve accurate reference values of penile and testicular measurements for Egyptian male newborns and infants. Therefore multicenter studies are recommended to establish Egyptian norms. ]]>
<![CDATA[Endogenous Factors in the Recovery of Reproductive Function After Testicular Injury and Cancer]]>https://www.eurekaselect.comarticle/77506 <![CDATA[The Influence of Cigarette Smoking on Sperm Quality and Sperm Membrane Integrity]]>https://www.eurekaselect.comarticle/73044 <![CDATA[Male Pelvic Pain: Beyond Urology and Chronic Prostatitis]]>https://www.eurekaselect.comarticle/72817 <![CDATA[Soybean and Processed Soy Foods Ingredients, and Their Role in Cardiometabolic Risk Prevention]]>https://www.eurekaselect.comarticle/68348 <![CDATA[Melatonin and Male Reproductive Health: Relevance of Darkness and Antioxidant Properties]]>https://www.eurekaselect.comarticle/67043 <![CDATA[Targeting Post-Ejaculation Sperm for Value-Added Contraception]]>https://www.eurekaselect.comarticle/64836 <![CDATA[The Male Peripubertal Phase as a Developmental Window for Reproductive Toxicology Studies]]>https://www.eurekaselect.comarticle/59042 <![CDATA[Cutaneous Complications of Anderson-Fabry Disease]]>https://www.eurekaselect.comarticle/55642 <![CDATA[Testosterone Deficiency Syndrome: Cellular and Molecular Mechanism of Action]]>https://www.eurekaselect.comarticle/54283

When the possible mechanisms for androgen actions are considered, one explanation emerges that androgen may act much like insulin in persons with type 2 diabetes mellitus: the degree of androgen resistance may be variable depending on the organs or systems considered. Therefore, the symptoms can result from altered or damaged synthesis of androgen synthesis or regulation, elevated androgen binding, a reduction in tissue response, or decreased as a result of polymorphism and aging. Genomic transcription and translation may also be affected.

As with diabetes, in adult male androgen deficiency, it is suggested that the definition of androgen deficiency should be based on individual physiology, with the requirements of the individual at a particular stage of life setting the baseline against which any deficiency of androgens or androgen metabolites, either absolute or relative, is determined. This approach will affect the terminology, etiology, diagnosis, and treatment of androgen deficiency.]]> <![CDATA[Current Guidelines and Strategies in Management of Renal Vein Thrombosis]]>https://www.eurekaselect.comarticle/52449 <![CDATA[Melatonin and Hypothalamic-Pituitary-Gonadal Axis]]>https://www.eurekaselect.comarticle/50545 <![CDATA[Female Infertility and Assisted Reproduction: Impact of Oxidative Stress-- An Update]]>https://www.eurekaselect.comarticle/46797 <![CDATA[Effectiveness of Gonadotropin Administration for Spermatogenesis Induction in Hypogonadotropic Hypogonadism: A Possible Role of Androgen Receptor CAG Repeat Polymorphism and Therapeutic Measures]]>https://www.eurekaselect.comarticle/44607 <![CDATA[ Recent Advances in Minimal Access Surgery for Infants and Children]]>https://www.eurekaselect.comarticle/1941 <![CDATA[ The INSL3-LGR8 Hormonal System in Humans: Testicular Descent, Cryptorchidism and Testicular Functions]]>https://www.eurekaselect.comarticle/35453 <![CDATA[ The Role of Oxidative Stress and Antioxidants in Assisted Reproduction]]>https://www.eurekaselect.comarticle/31612

Methods: Review of recent publications through Pubmed and the Cochrane data base.

Results: Oxidative stress is correlated with negatives ART outcomes. Both exogenous and endogenous sources of reactive oxygen species during IVF/ICSI are well established in the literature. Compared to IVF, ICSI is known to minimize the exposure of gametes to endogenous sources of oxidative stress. Strategies to control exogenous sources of oxidative stress within the ART setting include reducing visible/near UV light exposure, the addition of metal chelators to culture media, maintenance of low oxygen tension in the environment and the use of antioxidant therapy. Antioxidant supplementation of culture media with vitamin C, vitamin E, and melatonin has been investigated and yielded conflicting results. Whereas oral antioxidant supplementation of male patients has been accepted and is currently practiced, there is a lack of consensus regarding the effectiveness of supplementation of vitamin C, vitamin E and melatonin in females undergoing ART.

Conclusion: There is a need for further investigation with randomized controlled studies to confirm the efficacy and safety of antioxidant supplementation of culture media and patients as well as the need to determine the dosage required to improve fertilization rates and pregnancy outcome with IVF/ICSI. ]]> <![CDATA[ Impact of Environmental Toxicants on Testicular Function]]>https://www.eurekaselect.comarticle/27340 <![CDATA[ Germ Cell Apoptosis: Relevance to Infertility and Contraception]]>https://www.eurekaselect.comarticle/27339 <![CDATA[ Malformations of the Female Genital Tract and Embryological Bases]]>https://www.eurekaselect.comarticle/26783 <![CDATA[ Subject Index Volume 2]]>https://www.eurekaselect.comarticle/22823 <![CDATA[ Gabapentin and Pregabalin for the Acute Post-operative Pain Management. A Systematic-narrative Review of the Recent Clinical Evidences]]>https://www.eurekaselect.comarticle/14778 <![CDATA[ Testicular Cell Junction: A Novel Target for Male Contraception]]>https://www.eurekaselect.comarticle/13727 <![CDATA[ Gene Transfer to Sperm and Testis: Future Prospects of Gene Therapy for Male Infertility]]>https://www.eurekaselect.comarticle/11703 <![CDATA[ Mechanisms of Male Infertility: Role of Antioxidants]]>https://www.eurekaselect.comarticle/5980