New Advances on Endocrine Metabolic and Immune Diseases

(Recent Patents on Endocrine, Metabolic & Immune Drug Discovery)

ISSN (Print): 2666-9285
ISSN (Online): 2666-9293

Latest Issue: Volume 12 , Issue 1 , 2022

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Editorial Board


naemi Co-Editors naemi_se_Bermudez-sh_001 Bermúdez Valmore Universidad Simón Bolivar Cucuta Colombia

Dr. Valmore Bermúdez is a researcher at Universidad Simón Bolívar, Colombia, and a professor of Biochemistry and Human Metabolism at the School of Medicine in La Universidad del Zulia, Venezuela. He is also a member of the Endocrine and Metabolic Diseases Research Center at la Universidad del Zulia. He received his MGS degree in both Endocrinology and Epidemiology and a Ph.D. degree in Nutrition and Metabolism. His expertise includes epidemiology and endocrinology: metabolic syndrome, thyroid diseases, obesity, and type 2 diabetes. He is currently a member of the editorial board of Gaceta Médica de Caracas. He is also the author of 350 publications.

valmore@gmail.com v.bermudez@unisimonbolivar.edu.co
naemi_se_Sanctis-sh_001 De Sanctis Juan B. Palacký University Faculty of Medicine Olomouc Olomouc Czech Republic

Dr. Juan B. De Sanctis is a researcher at the Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University, Czech Republic and a Professor of Immunology and Biochemistry Institute of Immunology, Faculty of Medicine, Universidad Central de Venezuela. Member of FOCIS Center of Excellence in Immunology. He completed his PhD in Biochemistry and Immunology with an expertise in Inflammation, Metabolism, Flow Cytometry, Genetics, Pharmacology, and Immune response. Currently, Dr. Sanctis is a member of the editorial board of the journal Recent Patents on inflammation and allergy drug discovery. He has also served as a reviewer of 25 different journals. He has authored 175 publications and co-authored of two patents.

sanctisj@gmail.com
Section Editors naemi_se_Parati-sh_001 Parati Giancarlo University of Milano Milan Italy Cardiology. Blood pressure monitoring gianfranco.parati@unimib.it naemi_se_Ferrario-sh_001 Ferrario Carlos M. Department of Surgery, Department Social Sciences and Health Policy Wake Forest School of Medicine Winston-Salem NC USA

Ferrario’s research has advanced understanding and treatment of high blood pressure and vascular disease by identifying the mechanisms of action of angiotensin in the brain through his discovery of the area postrema as a site for the action of the hormone, the role of the heart in the development of arterial hypertension, and elucidating new endocrine pathways leading to the formation and action of angiotensins. Pioneering research in the renin-angiotensin system includes the discovery of the antihypertensive function of angiotensin-(1-7), the role of angiotensin converting enzyme 2 as a component of the opposing arm of the renin angiotensin system (3, 12), and the furthering of understanding as to how inhibitors of angiotensin converting enzyme and angiotensin receptor antagonists act on the body’s nervous and endocrine mechanisms to regulate blood pressure.

Hypertension and Cardiac Injury cferrario45@gmail.com cferrari@wakehealth.edu
naemi_se_Lopez-sh_001 Lopez-Jaramillo Patricio Santander University Bucaramanga Colombia

Patricio Lopez-Jaramillo was born in Quito, Ecuador, 10 February 1953. He is Medical Doctor by the Universidad Central del Ecuador in 1978, Endocrinologist by the Colegio Medico de Pichincha, Federación Médica del Ecuador in 1984, PhD in Pharmacology by the Faculdade de Medicina de Ribeirao Preto, Universidad de Sao Paulo, Brazil in 1987. In 2004 received the title of Specialist in Clinic Hypertension by the Universidad de Guadalajara, Mexico, and the Latin America Society of Hypertension (LASH). Nowadays is the Scientific Director of the Masira Research Institute, Medical School, Universidad de Santander (UDES) in Bucaramanga, Colombia, and Visiting Professor of the Eugenio Espejo Medical School of the Universidad UTE, in Quito, Ecuador.

Metabolic Syndrome, Hypertension and Cardiovascular Risk Factors jplopezj@gmail.com
naemi_se_Iturbe-sh_001 Rodriguez-Iturbe Bernardo Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán Mexico City Mexico

Médico Cirujano, Universidad del Zulia, Maracaibo, Venezuela, Residency in Internal Medicine and Fellowship Nephrology in the Graduate Hospital, University of Pennsylvania. ExPresident of the Latin American Society of Nephrology and Hypertension (2007-2009), and Ex-President of the International Society of Nephrology (2009-2011). Research interests: The role of autoimmunity in Hypertension, post streptococcal glomerulonephritis and pathophysiology of chronic kidney disease.

Nephrology brodrigueziturbe@gmail.com
naemi_se_Miranda-sh_001 Miranda Lopez J. Department of Medicine University of Cordoba Cordoba Spain

Full Professor of Internal Medicine. Director of the Department of Internal Medicine. Reina Sofia University Hospital. School of Medicine. University of Cordoba. Spain. Vice-Dean, School of Medicine. University of Cordoba. Spain. Prof. Lopez- Miranda has published almost 360 scientific articles in peer review journals, including The Lancet, Annals of Internal Medicine, Diabetes, Diabetes Care, Diabetologia, Arteriosclerosis Thrombosis and Vascular Biology, Journal of Clinical Endocrinology and Metabolism, American Journal of Clinical Nutrition, Journal of American College of Cardiology, Atherosclerosis, Journal of Lipid Research and the Journal of Nutrition. Moreover, Prof. López-Miranda has written reviews on the topic of Nutrition, Metabolic Syndrome, Postprandial Metabolism and coronary heart disease, diet and genetics, and the pathophysiology of arteriosclerosis. His “H” index is 51 at present.

Hypertension jlopezmir@uco.es
naemi_se_Ferri-sh_001 Ferri Claudio University of L’Aquila L’Aquila Italy

Claudio Ferri was born in Rome on June 1957 and received his degree in Medicine and his specialty in Internal Medicine at the University of Rome “La Sapienza”, where he began his studies on hypertension and its vascular consequence. He is currently Director of the Division of Internal Medicine and Nephrology at the University of L’Aquila – San Salvatore Hospital. He is also Full Professor of Internal Medicine and Director of the School of Internal Medicine and PhD in Internal Medicine and Public Health. During his career, he has published over 300 international peer reviewed papers (H index on Scopus = 53) on cardiovascular topics (particularly on drug and food impacts on the cardiovascular system). Most of published papers derives from international collaborations. Prof. Ferri is also the co-author of medical textbooks. Prof. Ferri is currently a member of the Scientific Council and Past-President of the Italian Society of Hypertension. He is regular member of the Regional Drug Committee and Ethics Committee. He won various national and international awards since he was a resident at the Rome University. He has conducted numerous clinical trials according to GCP.

Immunology and genetics of Hypertension claudio.ferri@univaq.it
naemi_se_Omboni-sh_001 Omboni Stefano Italian Institute of Telemedicine Solbiate Arno Italy Internal Medicine, Telemedicine stefano.omboni@iitelemed.org naemi_se_Munoz-sh_001 Munoz Luis E. Department of Internal Medicine 3—Rheumatology and Immunology Friedrich-Alexander University Erlangen Germany

Luis E. Muñoz Becerra, born in Venezuela, finished his medical studies at the Universidad de Oriente in 1999 and in 2002 he received his Master of Science in Immunology from the Universidad de Los Andes in Venezuela. He started his research career as an immunologist in 2002 with the analysis of autoantibody profiles of patients with SLE at the Institute for Clinical Immunology at the Universidad Central de Venezuela in Caracas. In 2004 he emigrated to Germany, where he completed his doctorate as Dr. med. in 2008 and then to Dr. rer. nat. in 2011 at the Friedrich-Alexander University in Erlangen-Nuremberg (FAU). Due to his fruitful research work on the biology of the neutrophil and its immunoregulatory properties, he obtained teaching qualifications at the FAU, where he now leads a junior working group in the Department of Internal Medicine 3 - Immunology and Rheumatology.

Autoimmunity Luis.Munoz@uk-erlangen.de
naemi_se_Israili-sh_001 Israili Zafar Emory University Atlanta GA USA

Zafar H Israili has completed his PhD in Medicinal Chemistry from the University of Kansas and has completed his training in Clinical Pharmacology from Emory University School of Medicine (EUSM). He is an Associate Professor of Medicine at EUSM and an Adjunct Professor of Chemistry at Georgia State University. He is also a Visiting Professor at the University of Fez, Morocco. He has work experience as an Adjunct Professor in Chemistry at the Emory University; Adjunct Professor in Pharmacology at Morehouse School of Medicine and as a Research Pharmacologist at Veterans Administration. He is an Associate Editor of Journal of Hypertension; Latin American Journal of Hypertension and Guest Editor of International Journal of Hypertension. Previously, he was the Editor of Ethnicity and Disease, Associate Editor/Editorial Board Member of Drug Metabolism Reviews and Drug Development Research. He is a reviewer for more than 60 medical- and scientific journals. He has published more than 200 research papers, reviews and book chapters.

Clinical Pharmacology. Antidiabetic agents zisrail@emory.edu
naemi_se_Israili-sh_001 Hurt-Camejo E. AstraZeneca and Karolinska Institute Solna Sweden Hypertension eva.hurt-camejo@astrazeneca.com naemi_se_de Mon Soto-sh_001 Soto Melchor Álvares Mon D. Universidad de Alcala Alcala de Henares Spain Immunological diseases mademons@gmail.com
Associate Editors naemi_ebm_Baptista_001 Baptista Trino Department of Physiology Los Andes University Medical School Merida Venezuela

Trino Baptista is a Venezuelan psychiatrist and Professor of Physiology and Biological Psychiatry at Los Andes University Medical School in Merida, Venezuela. His academic areas of interest are: 1) the metabolic effects of psychoactive drugs; 2) the safety of clozapine in subjects with psychoses; 3) the teaching of evolution theory in psychiatry; 4) the application of Arthur Schopenhauer’s thought in psychiatric education. He developed an animal model and conducted clinical trials evaluating the use of metformin for antipsychotic drug-induced weight gain and metabolic disturbances. He is also a clinical psychiatrist and provides drug treatments, cognitive therapy and transactional analysis.

trinbap@yahoo.com
naemi_ebm_Munoz-sh_001 Munoz Sergio R. University of La Frontera Temuco Chile sergio.munoz.n@ufrontera.cl naemi_ebm_Bellorin-Font-sh_001 Bellorin-Font Ezequiel Division of Nephrology Saint Louis University Saint Louis MO USA

Dr Ezequiel Bellorin-Font is a nephrologist specializing in the treatment of chronic kidney disease bone and mineral metabolism disorders, glomerular diseases, and disorders of calcium, phosphate, parathyroid hormone and vitamin D. He cares for patients in the hospital and clinic, including patients on dialysis. His research interests include chronic kidney disease and bone and mineral disorders. Dr. Bellorin-Font is an instructor in the Department of Internal Medicine, Division of Nephrology, at Saint Louis University School of Medicine. He is a member of the American Society of Nephrology, International Society of Nephrology and Latin American Society of Nephrology. Dr Bellorin-Font has worked for the advancement of nephrology in Venezuela and Latin America and the development of the World Atlas of Nephrology.

ebellorinfont@gmail.com
naemi_ebm_Acquatella-sh_001 Acquatella Harry Universidad Central de Venezuela Caracas Venezuela

Dr Aquatella is internationally-recognized for his expertise and scientific contributions in Chagasic Myocardiopathy and echocardiography, as well as a medical professor and researcher. Dr Aquatella is a board-certified and fellowship-trained in Medicine, Cardiology and Echocardiology who received his MD degree and his Doctorate in Medical Sciences at the Universidad Central de Venezuela. He works at the Department of Internal Medicine as a Professor in the Division of Cardiology at University Hospital of Caracas and Caracas Medical Center. Dr Aquatella is a standing member and past president of the National Academy of Medicine, and past member of the Scientific Council on Cardiomyopathies of the International Society and Federation of Cardiology from 1980 to 1989. He has served as President of The Fogarty Commission of The USA National Institute of Health for Venezuela and on the editorial boards of Latin American Journal of Hypertension, and Venezuelan Archives of Pharmacology.

hacquatella@gmail.com
Editorial Board Members naemi_ebm_duque-gmv_001 Duque Gloria M.V. Universidad de Antioquia Medellín Colombia glomavas@gmail.com naemi_ebm_blanca-i_001 Blanca Isaac Universidad Central de Venezuela Caracas Venezuela

Doctor (PhD) in Physiological Sciences from the Universidad Central de Venezuela (UCV). Magister Scientiarum in Immunology from the Instituto Venezolano de Investigaciones Científicas (IVIC). Postdoctoral studies in Experimental Immunology at NIH, National Cancer Institute at Frederick Maryland, USA. Full professor of cellular immunology and cáncer at the Institute of Immunology, Faculty of Medicine (UCV). Director of the Institute of Immunology as FOCIS Center of Excellence in Clinical Immunology (FCE). Research interest: the study of natural killer (NK) cells and their regulatory role in the adaptive immune response and as an effector mechanism against malignant cells.

Isaac.blanca@gmail.com
naemi_ebm_uzcategui-nl_001 Uzcategui Nestor L. Universidad Central de Venezuela Caracas Venezuela

Dr. Uzcátegui earned his Ph.D. in Biochemistry at the University of Tübingen (Germany). He is a full professor at the Central University of Venezuela and currently a researcher at the University of Tübingen (Germany). His research interests are related to membrane protein, autophagy, cellular signalling, and regulated cell death in health and disease, with a special emphasis on infectious diseases.

nestor.uzcategui@uni-tuebingen.de
naemi_ebm_martinez-ga_001 Martinez Gustavo A. Simon Bolivar University Barranquilla Colombia garoca1@hotmail.com naemi_ebm_pinto-el_001 Pinto Edgar Leal Northeastern University Boston MA USA

Dr Leal-Pinto ́s entire career, and most recent work in the Logothetis lab at North Eastern University, has been aimed at developing the lipid bilayer as an assay for ion channel activity. Most recent work is exemplified by his recent contribution to the gating of a G protein-sensitive K+ channel. In the past year, in a team with Dr Louis De Felice we discussing the possibility of studying neurotransmitter transporters in bilayers, overexpressing hDAT in oocytes, prepare liposomes from the surface membranes and fuse these to the planar bilayer, a result with significant implications for understanding neurotransmitter transporters and well suited for the R21 mechanism. Dr Leal-Pinto has been performing lipid bilayer experiments for more than 20 years. He successfully reconstituted and studied a large number of channel systems, including the multidrug resistance protein, an inwardly rectifying K+ channel, a urate channel/transporter, and a nucleic acid channel. He has developed the support protocols for such studies, including a separation method using personal to purify membranes, a sonication process to make proteoliposomes for fusion with planar bilayers, and optimization of the lipid composition of the bilayer for superior reconstitution. As PI or Co-Investigator on several previous universities- and NIH- funded grants, he collaborated with other researchers and produced several peer- reviewed publications from each project.

elealpinto1941@gmail.com
naemi_ebm_garmendia-jv_001 Garmendia Jenny V. Universidad Central de Venezuela Caracas Venezuela

Dr Garmendia is Medical Doctor, MSc in Clicial Immunology and Internal Medicine. She is an Agregate Professor of Clinical Immunology at the Faculty of Medicine in Caracas. Venezuela. Her expertise is in immunology related clinical diseases, allergy, atuoiimune diseases, disease of pregnancy and fertility. She has published over 45 international papers and she is currently involved in telemedicine for pregnancy and in prodiving advise as clinical immunologist in the current coronavirus outbrake.

jenny.garmendia@gmail.com
Executive Guest Editors naemi_ebm_tapia-fj_001 Tapia Felix J. Universidad Central de Venezuela Caracas Venezuela

Felix J. Tapia. Biologist from Concordia University, Montreal, Canada and immunologist from the University of London, UK. Full professor at the Universidad Central de Venezuela (UCV) and Head of the Laboratory of Molecular Biology, Instituto de Biomedicina, UCV. In 2005, he awarded by the most prestigious scientific award in Venezuela: Premio Fundación Empresas Polar “Lorenzo Mendoza Fleury” 2005. He was a member of editorial boards from the following scientific journals:Histology and Histopathology, Acta Microscopica, Dermatologia Venezolana, Vitae, Immunobiology; and currently is Editor in Our Dermatology, Journal of Microbiology & Experimentation and International Journal of Clinical Dermatology & Research.

felix.tapia@gmail.com
naemi_ebm_israel-a_001 Israel Anita Universidad Central de Venezuela Caracas Venezuela

Anita Israel, Pharmacist, Ph.D. in Pharmacology, Full Professor and Chief Researcher at the Laboratory of Neuropeptides, School of Pharmacy, Universidad Central de Venezuela. Visiting Fellow in the Section on Pharmacology, NIH, Bethesda, Maryland. Research area: Neuroscience and Neuropharmacology, related to molecular and physiological aspects of endocrine and cardiovascular regulation, and intracellular signaling mechanisms of brain neuropeptide receptors. Developing project: new biomarkers in hypercholesterolemia and metabolic syndrome in Venezuelan population. Scientific production 475 abstracts, 3 books, and 207 publications. Direction of 14 Ph.D. and 6 Magister Theses. Honored with numerous awards. Editor in Chief: Revista de la Facultad de Farmacia.

astern88@gmail.com
naemi_ebm_rangel-aldao-r_001 Rangel-Aldao Rafael Simon Bolivar University Caracas Venezuela

Rafael Rangel-Aldao received his MD from Universidad Central de Venezuela, in Caracas. and holds a Ph.D. from Albert Einstein College of Medicine in New York. Dr. Rangel-Aldao has served at leading positions as an Academic, Inventor, and Director of Research in Venezuela, as well as a visiting professor at major universities of America and Europe. He has published extensively on biotechnology, biochemistry, molecular biology, chemistry, plant physiology, and biomedical research, and food product development. His scientific publications cover research papers, international patents on medicine and foodstuffs, invited review articles, letters, and book chapters edited by eminent scientists.

rrangel@usb.ve
naemi_ebm_ponte-sucre-r_001 Ponte-Sucre Alicia Central University of Venezuela Caracas Venezuela

Alicia Ponte-Sucre is Emeritus Full Professor in Human Physiology (MSc-Physiology and Biophysics, DSc- Pharmacology), Faculty of Medicine (Fac-Med), Universidad Central de Venezuela (UCV), and lecturer at Graduate Courses and member of evaluation committees at Fac-Med, Pharmacy and Sciences, UCV. Her interests focus on Trypanosomatidae (Leishmania and Trypanosoma): parasite-host interaction, adaptability and its role in drug resistance, therapeutic tools development against these parasites. She has 75 publications, 111 participations in seminars and symposia and 176 free communications. She has edited four books (Horizon, Springer Verlag, and Fundación Telefónica). She has been (Fac-Med, UCV): Chair of Human Physiology, Coordinator of Graduate Programs in Physiological Sciences, Scientific Affairs Coordinator. She has scientific affiliations and has been: international project advisor, world-wide institutions and journals referee, member of academic commissions and directorates and organizing committees, and invited visiting Professor [Würzburg University (Uni-Wü-DE)].

aiponte@gmail.com
naemi_ebm_rodriguez-ma_001 Rodriguez Martin A. University of Texas Medical Branch Galveston TX USA

Medical degree at Universidad Central de Venezuela, Caracas, 1971 · Fellowship Immunology/Rheumatology, University of New Mexico, USA, 1982 · Magister Scientiarum Internal Medicine, Universidad Central de Venezuela, Caracas, 1990 · Doctorate degree in Medical Sciences, Universidad del Zulia, Maracaibo, Venezuela, 2005 · Director Centro Nacional de Enfermedades Reumaticas, Hospital Universitario de Caracas, 1998‐2014 · Chief Division of Rheumatology, Hospital Universitario de Caracas, · Head Research Centro Nacional de Enfermedades Reumaticas, Hospital Universitario de Caracas, 2014‐2018 · Visiting Scholar Sealy Center on Aging, University of Texas Medical Branch, Galveston, Texas 2019‐ · Research interest: systemic autoimmune diseases, systemic lupus erythematosus, rheumatoid arthritis, T‐lymphocytes, clinical features.

martarod@utmb.edu
naemi_ebm_bianchini-rgc_001 Bianchini Raul Giulio Carlini University Hospital Caracas Venezuela raul.carlini@gmail.com naemi_ebm_romano-mc_001 Romano Marta C. CINVESTAV Mexico City Mexico mromano@fisio.cinvestav.mx
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