Glioblastoma multiforme (GBM) is the most common and aggressive primary brain tumor in humans. Despite aggressive surgical resection using state-of-theart neuroimaging and radiochemotherapy, the prognosis of GBM remains poor, with an estimated median survival of 12-14 months. At presentation, tumor cells have already have migrated into normal brain tissue beyond the main tumor mass. This accounts for the inability of surgery to cure this tumor. It is therefore imperative to better understand how inhibit GBM cell migration. In this review, we describe various potential targets that may be exploited to inhibit the migration GBM cells.