Abstract
Several processes including endothelial angiogenesis, vascular neointimal lesion formation, vascular inflammation process, lipoprotein metabolism, and hypertension are critically involved in atherosclerosis. This chapter aims to introduce the role of miRNAs in neointimal formation. Neointimal formation is a common pathological lesion in diverse cardiovascular diseases occurring at sites of subclinical atherosclerosis but are also classical hallmarks of restenosis after stenting, angioplasty, endarterectomy, and arterial transplantation. Neointimal growth is the balance between proliferation and apoptosis of vascular smooth muscle cells. A number of miRNAs, miR-21, miR-143, miR-145, miR-221, and miR-222, have been demonstrated to play important role in neointimal formation. Their corresponding target genes have also been established.
Related Journals
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry
Current Diabetes Reviews
Current Neurovascular Research
Current Respiratory Medicine Reviews
Current Pediatric Reviews
Infectious Disorders - Drug Targets
Current Stem Cell Research & Therapy
Endocrine, Metabolic & Immune Disorders - Drug Targets
Current Alzheimer Research
Current Aging Science
Related Books
Andrology: Current and Future Developments
Male Infertility: An Integrative Manual of Western and Chinese Medicine
Awake Thoracic Surgery
The Anatomical Foundations of Regional Anesthesia and Acute Pain Medicine Macroanatomy Microanatomy Sonoanatomy Functional anatomy
Frontiers in Anti-infective Agents
Frontiers in Anti-infective Agents
Frontiers in Anti-infective Agents
Frontiers in Anti-infective Agents
Frontiers in Anti-infective Agents
Frontiers in Anti-infective Agents