Journal: Mini-Reviews in Medicinal Chemistry
Guest editor(s):Dr. Yu Zhang
Co-Guest Editor(s): Ping Wang ,

Introduction

Natural products have always been one of the important ways of drug discovery due to their novel skeleton and diverse functional group characteristics. According to statistics, between 1981 and 2019, the FDA approved a total of 1,394 small molecule drugs for marketing, of which 930 marketed drugs originated from the modification or modification of natural products, accounting for 66.7%, while only about 70 new drugs were directly derived from natural products. As a result, drug innovation relies heavily on discovering and improving natural active molecules from traditional natural products. The study of structure-activity relationship is the cornerstone of the optimization of the druggability of natural active molecules, and the efficient synthesis and structural modification of natural products are required to achieve this goal. Therefore, this issue will focus on the recent progress in the efficient synthesis and structural modification of natural products, the study of pharmacological activities, the structure-activity relationship and the optimization of druggability. It is hoped that this topic can provide some enlightenment and help for natural product-based drug discovery.

Keywords

Natural products;, Total synthesis and modification, pharmacological activities, structure-activity relationship, druggability

Sub-topics