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Cardiovascular & Hematological Disorders-Drug Targets

Editor-in-Chief

ISSN (Print): 1871-529X
ISSN (Online): 2212-4063

New Oral Anticoagulation after Heart Valve Replacement

Author(s): Ibrahim El-Battrawy, Stefan Baumann, Aydin Huseynov and Ibrahim Akin

Volume 15 , Issue 2 , 2015

Page: [106 - 109] Pages: 4

DOI: 10.2174/1871529X1502151209111735

Price: $65

Abstract

Antithrombotic treatment after heart valve surgery is of utmost importance depending on the type of used valve. Since in the early 1960s, oral anticoagulation with vitamin K antagonist are the gold-standard for prevention of thromboembolism at replaced heart valves. The introduction of new oral anticoagulation has dramatically changed treatment strategy in patients with atrial fibrillation and in patients with venous thromboembolism like deep vein thrombosis and pulmonary embolism. However, to date, the use of these newer drugs is contraindicated after implantation of mechanical heart valves for prevention of thromboembolism. Large trial revealed significantly higher rates of thromboembolism and bleeding events as compared to oral anticoagulation. Further studies are required to evaluate the several newer oral anticoagulations in patients with mechanical heart valve.

Keywords: Coumadin, heart valve, novel oral anticoagulation, surgery, warfarin.

Graphical Abstract

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