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Current Drug Targets

Eiditor-in-Chief

ISSN (Print): 1389-4501
ISSN (Online): 1873-5592

Current Perspectives on Novel Drug Delivery Systems and Approaches for Management of Cervical Cancer: A Comprehensive Review

Author(s): Umme Hani, Riyaz Ali M. Osmani, Rohit R. Bhosale, Hosakote Gurumallappa Shivakumar and Parthasarathi K. Kulkarni

Volume 17 , Issue 3 , 2016

Published on: 05 May, 2015

Page: [337 - 352] Pages: 16

DOI: 10.2174/1389450116666150505154720

Price: $65

Abstract

Cervical cancer is uterine cervix carcinoma, the second deadly cancer and has a high incidence and mortality rate. In the developing world conventional treatment strategies such as surgical intervention and chemoradiotherapy are less widely available. Currently cancer research focuses on improving treatment of cervical cancer using various therapies such as gene therapy, recombinant protein therapy, photodynamic therapy, photothermal therapy and delivery of chemotherapeutic agents using nanoparticles, hydrogel and liposomal based delivery systems and also localized delivery systems which exist in a variety of forms such as intravaginal rings, intravaginal patches, intravaginal films, etc. in order to improve the drug delivery in a controlled manner to the diseased site thereby reducing systemic side effects. The present review encloses existing diverse delivery systems and approaches intended for treatment of cervical cancer.

Keywords: Angiogenesis, cervical cancer, delivery systems, drug targets, human papillomavirus, neoplasia.

Graphical Abstract

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