Abstract
Platinum (Pt)-based pharmaceutical drugs are among the most active agents utilized for the therapy of cancer. Carboplatin, cisplatin and oxaliplatin are three members of the platinum anticancer drug family approved by Food and Drug Administration (FDA). Despite gaining enormous success, the extensive application and efficacy of these drugs are often impeded by toxic side effects, their susceptibility to acquired drug resistance, and limited activity against many human cancers. These compounds are known to induce the apoptosis of tumor cells by binding to nuclear DNA, forming a variety of structural adducts to trigger cellular responses. To better understand the anticancer treatment with Pt-based chemotherapeutics, pharmaceutical formulations in perfect quality are required and the behavior of the drugs must be studied at therapeutically relevant levels by separation and detection of the intact drug and its individual biotransformation species in clinical samples. In this review, Pt-based drugs are introduced and the detection methods of Ptbased adduct with DNA and protein have been discussed.
Keywords: Anticancer drugs, adducts, detection, platinum.
Graphical Abstract
Call for Papers in Thematic Issues
Advances of Heterocyclic Chemistry with Pesticide Activity
Global food safety and security will continue to be a global concern for the next 50 years and beyond. Plant diseases have had a significant impact on food safety and security throughout the entire food chain, from primary production to consumption. While conventional chemical pesticides have been traditionally used for ...read more
Calculation design of covalent/metal organic framework based catalysts
This research area combines theoretical computation and screening with machine learning for the design of covalent/metal organic framework-based catalysts, bridging the disciplines of organic chemistry, physical chemistry, computational chemistry, materials science, and machine learning. It covers several critical aspects: designing and synthesizing organic catalysts for improved performance, applying computational methods ...read more
Carbohydrates conversion in biofuels and bioproducts
Biomass pretreatment, hydrolysis, and saccharification of carbohydrates, and sugars bioconversion in biofuels and bioproducts within a biorefinery framework. Carbohydrates derived from woody biomass, agricultural wastes, algae, sewage sludge, or any other lignocellulosic feedstock are included in this issue. Simulation, techno-economic analysis, and life cycle analysis of a biorefinery process are ...read more
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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