Abstract
With the recent emergence of novel technologies, the field of biomarker discovery has been the subject of intense research and activity. Major advances in cancer control will be greatly aided by early detection for the diagnosis and treatment of cancer in its pre-invasive state. Cancer being a diverse disease involves alterations in three classes of genes viz. (proto) oncogenes, tumour suppressor genes and DNA repair genes offering a wide variety of opportunities for the development of biomarkers. The emergence of innovative technologies in genomics, proteomics, metabolomics and imaging allows researchers to facilitate inclusive analysis of cancer cells. These approaches have already demonstrated its power to discriminate cancer cells from normal cells and to identify specific genetic elements involved in cancer progression. Cancer evolves via manifold pathways and is a culmination of a variety of genetic, molecular and clinical events. In the past few years, several reports have led to identification of novel cancer signatures via high throughput biology. Current review gives an overview of the bioinformatics tools, cancer database and available software package tools and further summarizes about different strategies involved in Omics research (genomics, proteomics, metabolomics) for the development of cancer biomarkers. We also discuss about the current and emerging biomarkers in breast cancer with fundamental insight into different markers used in breast cancer detection. In addition, we focus upon the systematic integration of various omic data for accelerating cancer biomarker discovery with evidence based cancer management. The above strategies may lead to significant improvement in cancer screening, prognosis and management of therapeutic response in cancer patients.
Keywords: Biomarkers, cancer, genomics, imaging, metabolomics, proteomics, diagnostic markers, validation.
Current Cancer Drug Targets
Title:Prognostic and Predictive Biomarkers in Cancer
Volume: 14 Issue: 5
Author(s): Meera Nair, Sardul Singh Sandhu and Anil K. Sharma
Affiliation:
Keywords: Biomarkers, cancer, genomics, imaging, metabolomics, proteomics, diagnostic markers, validation.
Abstract: With the recent emergence of novel technologies, the field of biomarker discovery has been the subject of intense research and activity. Major advances in cancer control will be greatly aided by early detection for the diagnosis and treatment of cancer in its pre-invasive state. Cancer being a diverse disease involves alterations in three classes of genes viz. (proto) oncogenes, tumour suppressor genes and DNA repair genes offering a wide variety of opportunities for the development of biomarkers. The emergence of innovative technologies in genomics, proteomics, metabolomics and imaging allows researchers to facilitate inclusive analysis of cancer cells. These approaches have already demonstrated its power to discriminate cancer cells from normal cells and to identify specific genetic elements involved in cancer progression. Cancer evolves via manifold pathways and is a culmination of a variety of genetic, molecular and clinical events. In the past few years, several reports have led to identification of novel cancer signatures via high throughput biology. Current review gives an overview of the bioinformatics tools, cancer database and available software package tools and further summarizes about different strategies involved in Omics research (genomics, proteomics, metabolomics) for the development of cancer biomarkers. We also discuss about the current and emerging biomarkers in breast cancer with fundamental insight into different markers used in breast cancer detection. In addition, we focus upon the systematic integration of various omic data for accelerating cancer biomarker discovery with evidence based cancer management. The above strategies may lead to significant improvement in cancer screening, prognosis and management of therapeutic response in cancer patients.
Export Options
About this article
Cite this article as:
Nair Meera, Sandhu Singh Sardul and Sharma K. Anil, Prognostic and Predictive Biomarkers in Cancer, Current Cancer Drug Targets 2014; 14 (5) . https://dx.doi.org/10.2174/1568009614666140506111118
DOI https://dx.doi.org/10.2174/1568009614666140506111118 |
Print ISSN 1568-0096 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5576 |
Call for Papers in Thematic Issues
Advances in Cancer Biomarkers and Potential Drug Targets: From Diagnosis to Therapy
Cancer biomarkers play a crucial role in the diagnosis, prognosis, and treatment of cancer. They provide valuable information for cancer detection, risk assessment, treatment selection, and monitoring response to therapy. With advancements in molecular biology and high-throughput technologies, there has been an increasing interest in identifying and characterizing cancer biomarkers ...read more
Novel Therapeutic Approaches to Target Drug Resistant Tumors
With the development of disciplines such as chemical biology and molecular biology, the genes or proteins closely related to tumor occurrence and development have gradually become clear. Targeted therapies targeting these genes or proteins provide more effective methods for tumor treatment. Tumor targeted drugs generally only act on specific targets ...read more
ROLE OF IMMUNE AND GENOTOXIC RESPONSE BIOMARKERS IN TUMOR MICROENVIRONMENT IN CANCER DIAGNOSIS AND TREATMENT
Biological biomarkers have been used in medical research as an indicator of a normal or abnormal process inside the body, or of a disease. Nowadays, various researchers are in process to explore and investigate the biological markers for the early assessment of cancer. DNA Damage response (DDR) pathways and immune ...read more
Targeting the battlefield between host and tumor: basic research and clinical practice on reshaping tumor immune microenvironment
Immune system protects host against malignant tumors through effector cells and molecules. Cancer development and its response to therapy are regulated by inflammation, which either promotes or suppresses cancer progression. Chronic inflammation facilitates cancer progression and treatment resistance, whereas induction of acute inflammatory reactions often lead to anti-cancer immune responses. ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Therapeutic Cancer Vaccines: At Midway Between Immunology and Pharmacology
Current Cancer Drug Targets Current Trends and Future Directions of Fluoroquinolones
Current Medicinal Chemistry Can Genetics Help in Treatment of Smoking Addiction?
Current Pharmacogenomics and Personalized Medicine An Antifungal Peptide with Antiproliferative Activity Toward Tumor Cells from Red Kidney Beans
Protein & Peptide Letters Non-Analgesic Effects of Opioids: Opioids and the Endocrine System
Current Pharmaceutical Design Mammalian Target of Rapamycin (mTOR) Inhibitors as Anti-Cancer Agents
Current Cancer Drug Targets Prospective Function of Different Antioxidant Containing Natural Products in the Treatment of Neurodegenerative Diseases
CNS & Neurological Disorders - Drug Targets Optical and Multimodal Peptide-Based Probes for In Vivo Molecular Imaging
Anti-Cancer Agents in Medicinal Chemistry Continuous Nanostructures for the Controlled Release of Drugs
Current Pharmaceutical Design Cellular Energetical Actions of “Chemical” and “Surgical” Vagotomy in Gastrointestinal Mucosal Damage and Protection: Similarities, Differences and Significance for Brain-Gut Function
Current Neuropharmacology Targeting Proliferating Cell Nuclear Antigen (PCNA) as an Effective Strategy to Inhibit Tumor Cell Proliferation
Current Cancer Drug Targets Therapeutic Immunoconjugates. Which Cytotoxic Payload: Chemotherapeutic Drug (ADC) or Radionuclide (ARC) ?
Current Cancer Therapy Reviews New Strategies for Managing Anemia of Chronic Kidney Disease
Cardiovascular & Hematological Agents in Medicinal Chemistry Editorial [Hot Topic: Protein Targets in the Treatment of Cancers (Guest Editor: Sabbir Ahmed)]
Anti-Cancer Agents in Medicinal Chemistry Basic and Clinical Research Against Advanced Glycation End Products (AGEs): New Compounds to Tackle Cardiovascular Disease and Diabetic Complications
Recent Advances in Cardiovascular Drug Discovery (Discontinued) Anti-EGFR Strategy for Colorectal Cancer: Searching for the Real Target
Letters in Drug Design & Discovery Tamoxifen: A Synthetic Overview
Current Organic Chemistry Pathobiology and Therapeutic Implications of Tumor Acidosis
Current Medicinal Chemistry Characterization of Gemcitabine Loaded Polyhydroxybutyrate Coated Magnetic Nanoparticles for Targeted Drug Delivery
Anti-Cancer Agents in Medicinal Chemistry The Sea Urchin, Paracentrotus lividus, as a Model to Investigate the Onset of Molecules Immunologically Related to the α-7 Subunit of Nicotinic Receptors During Embryonic and Larval Development
Current Drug Targets