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Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1871-5230
ISSN (Online): 1875-614X

Colchicine: An Old Wine in a New Bottle?

Author(s): Francois Roubille, Ekaterini Kritikou, David Busseuil, Stephanie Barrere-Lemaire and Jean-Claude Tardif

Volume 12, Issue 1, 2013

Page: [14 - 23] Pages: 10

DOI: 10.2174/1871523011312010004

Price: $65

Abstract

Although colchicine, a natural product, is one of the oldest drugs still currently available, its possible functions seem to be surprisingly not well-known. Beyond its present medicinal use (gout, familial Mediterranean fever, Behcet’s disease, chondrocalcinosis and other crystal arthritis), numerous other conditions have been recently proposed for the use of this drug, including pericardial diseases. However, colchicine appears as a double-edged sword, with underestimated toxicity and frequent side effects. In this review, we present the main pharmacologic features of this drug, with an emphasis on toxicity and highlight its possible applications in the cardiovascular field.

Keywords: Colchicine, pericardial diseases, pericarditis, gout, tubulin, inflammation, cardiovascular diseases


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