Abstract
The present review summarizes the existing literature data regarding the development of newer categories of antidiabetic agents, their mechanism of action and their clinical importance. In this paper, a review of the recent patents for the treatment of diabetes will be presented. In recent years significant achievements have been done, including the development of SGLT2 inhibitors, glucokinase activators as well as the role of free fatty acids and bile acid metabolism in the treatment of diabetes are reviewed.
Keywords: Bile acid synthesis, Low density lipoprotein cholesterol, sodium-coupled glucose transporters, free fatty acids, glucokinase activators, SGLT2 inhibitors, Dapagliflozin, Type 2 diabetes mellitus, Diet-induced obesity
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery
Title: Challenges for the Treatment of Diabetes Mellitus
Volume: 5 Issue: 3
Author(s): Athanasia K. Papazafiropoulou, Marina S. Kardara and Stavros I. Pappas
Affiliation:
Keywords: Bile acid synthesis, Low density lipoprotein cholesterol, sodium-coupled glucose transporters, free fatty acids, glucokinase activators, SGLT2 inhibitors, Dapagliflozin, Type 2 diabetes mellitus, Diet-induced obesity
Abstract: The present review summarizes the existing literature data regarding the development of newer categories of antidiabetic agents, their mechanism of action and their clinical importance. In this paper, a review of the recent patents for the treatment of diabetes will be presented. In recent years significant achievements have been done, including the development of SGLT2 inhibitors, glucokinase activators as well as the role of free fatty acids and bile acid metabolism in the treatment of diabetes are reviewed.
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Cite this article as:
K. Papazafiropoulou Athanasia, S. Kardara Marina and I. Pappas Stavros, Challenges for the Treatment of Diabetes Mellitus, Recent Patents on Endocrine, Metabolic & Immune Drug Discovery 2011; 5 (3) . https://dx.doi.org/10.2174/187221411797265953
DOI https://dx.doi.org/10.2174/187221411797265953 |
Print ISSN 1872-2148 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3334 |
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