Abstract
The labeling of probes with fluorine-18 [18F, β(+); 96.7%] continues to play a considerably important role in the development of positron emission tomography (PET) as a modality for both clinical research and clinical diagnoses. This review summarizes the strategies and recent developments in the fluorine-18 labeling of probes for PET imaging. Problems and issues relating to the practical production of fluorine-18 currently in widespread use are also discussed.
Keywords: Probe, fluorination, F-18, positron emission tomography (PET), molecular imaging, labeling chemistry, radiotracer, radiochemists, radiopharmaceuticals, solid-phase, microfluidics, microwave chemistry
Medicinal Chemistry
Title: Labeling Strategies with F-18 for Positron Emission Tomography Imaging
Volume: 7 Issue: 5
Author(s): Yonghong Gu, Dong Huang, Zhiguo Liu, Jiaguo Huang and Wenbin Zeng
Affiliation:
Keywords: Probe, fluorination, F-18, positron emission tomography (PET), molecular imaging, labeling chemistry, radiotracer, radiochemists, radiopharmaceuticals, solid-phase, microfluidics, microwave chemistry
Abstract: The labeling of probes with fluorine-18 [18F, β(+); 96.7%] continues to play a considerably important role in the development of positron emission tomography (PET) as a modality for both clinical research and clinical diagnoses. This review summarizes the strategies and recent developments in the fluorine-18 labeling of probes for PET imaging. Problems and issues relating to the practical production of fluorine-18 currently in widespread use are also discussed.
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Cite this article as:
Gu Yonghong, Huang Dong, Liu Zhiguo, Huang Jiaguo and Zeng Wenbin, Labeling Strategies with F-18 for Positron Emission Tomography Imaging, Medicinal Chemistry 2011; 7 (5) . https://dx.doi.org/10.2174/157340611796799140
DOI https://dx.doi.org/10.2174/157340611796799140 |
Print ISSN 1573-4064 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6638 |
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