Abstract
Chemiluminescence has traditionally been used to study the nature of the oxidative bactericidal mechanisms of neutrophils and monocytes, intrinsic defects of abnormally functioning neutrophils or monocytes and cell activation. During the last ten years, Chemiluminescence has been applied in a wide variety of techniques, including immunoassays, protein blotting and toxicological and pharmacological tests (e.g. after exposure to antibiotic or immunomodulators agents, such as adjuvants and cytotoxic drugs). In this review, we discuss some promising clinical applications of Chemiluminescence in clinical immunology for the study of autoimmune diseases, inflammatory responses, endocrine disorders, immunodeficient states, mucosal immune responses against drugs and pathogens and host responses against tumors and infections. Further, we review the numerous advantages of Chemiluminescence-based methods over other methods to assay the same endpoints, which facilitate their use in the current practice of clinical immunology.
Keywords: Chemiluminescence assays, phagocytic activity, clinical immunology, tumors, immunodeficiency's states, inflammatory response, infectious diseases, endocrine disorders, cell activation, adjuvants, cytotoxic drugs, autoimmune diseases, inflammatory responses, immunodeficiencys states, electromagnetic radiation, neutrophils, PMN, monocytes, MN, NADPH oxidase, Luminol, singlet oxygen, superoxide anion, hydrogen peroxide, hypochlorous acid, IL-1 receptor antagonist, Nitric Oxide (NO)/peroxynitrite formation, polymorphonuclear leukocytes, rheumatism, PCR/RT-PCR techniques, metabolic ketosis, Neuramidinase inhibitors, Treponema pallidum, A. phagocytophilum, Chlamydia pneumoniae, growth hormone, prolactine, Vitamin E
Mini-Reviews in Medicinal Chemistry
Title: Recent Applications of Chemiluminescence Assays in Clinical Immunology
Volume: 10 Issue: 14
Author(s): A. R. Rodriguez-Orozco, H. Ruiz-Reyes and N. Medina-Serriteno
Affiliation:
Keywords: Chemiluminescence assays, phagocytic activity, clinical immunology, tumors, immunodeficiency's states, inflammatory response, infectious diseases, endocrine disorders, cell activation, adjuvants, cytotoxic drugs, autoimmune diseases, inflammatory responses, immunodeficiencys states, electromagnetic radiation, neutrophils, PMN, monocytes, MN, NADPH oxidase, Luminol, singlet oxygen, superoxide anion, hydrogen peroxide, hypochlorous acid, IL-1 receptor antagonist, Nitric Oxide (NO)/peroxynitrite formation, polymorphonuclear leukocytes, rheumatism, PCR/RT-PCR techniques, metabolic ketosis, Neuramidinase inhibitors, Treponema pallidum, A. phagocytophilum, Chlamydia pneumoniae, growth hormone, prolactine, Vitamin E
Abstract: Chemiluminescence has traditionally been used to study the nature of the oxidative bactericidal mechanisms of neutrophils and monocytes, intrinsic defects of abnormally functioning neutrophils or monocytes and cell activation. During the last ten years, Chemiluminescence has been applied in a wide variety of techniques, including immunoassays, protein blotting and toxicological and pharmacological tests (e.g. after exposure to antibiotic or immunomodulators agents, such as adjuvants and cytotoxic drugs). In this review, we discuss some promising clinical applications of Chemiluminescence in clinical immunology for the study of autoimmune diseases, inflammatory responses, endocrine disorders, immunodeficient states, mucosal immune responses against drugs and pathogens and host responses against tumors and infections. Further, we review the numerous advantages of Chemiluminescence-based methods over other methods to assay the same endpoints, which facilitate their use in the current practice of clinical immunology.
Export Options
About this article
Cite this article as:
R. Rodriguez-Orozco A., Ruiz-Reyes H. and Medina-Serriteno N., Recent Applications of Chemiluminescence Assays in Clinical Immunology, Mini-Reviews in Medicinal Chemistry 2010; 10 (14) . https://dx.doi.org/10.2174/138955710793564142
DOI https://dx.doi.org/10.2174/138955710793564142 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
Call for Papers in Thematic Issues
Bioprospecting of Natural Products as Sources of New Multitarget Therapies
According to the Convention on Biological Diversity, bioprospecting is the exploration of biodiversity and indigenous knowledge to develop commercially valuable products for pharmaceutical and other applications. Bioprospecting involves searching for useful organic compounds in plants, fungi, marine organisms, and microorganisms. Natural products traditionally constituted the primary source of more than ...read more
Computational Frontiers in Medicinal Chemistry
The thematic issue "Computational Frontiers in Medicinal Chemistry" provides a robust platform for delving into state-of-the-art computational methodologies and technologies that significantly propel advancements in medicinal chemistry. This edition seeks to amalgamate top-tier reviews spotlighting the latest trends and breakthroughs in the fusion of computational approaches, including artificial intelligence (AI) ...read more
Natural Products and Dietary Supplements in Alleviation of Metabolic, Cardiovascular, and Neurological Disorders
Metabolic disorders like diabetes, obesity, inflammation, oxidative stress, cancer etc, cardiovascular disorders like angina, myocardial infarction, congestive heart failure etc as well as neurological disorders like Alzheimer?s, Parkinson?s, Epilepsy, Depression, etc are the global burden. They covered the major segment of the diseases and disorders from which the human community ...read more
Natural Products in Drug Discovery
Natural products have always been one of the important ways of drug discovery due to their novel skeleton and diverse functional group characteristics. According to statistics, between 1981 and 2019, the FDA approved a total of 1,394 small molecule drugs for marketing, of which 930 marketed drugs originated from the ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Nutraceuticals and "Repurposed" Drugs of Phytochemical Origin in Prevention and Interception of Chronic Degenerative Diseases and Cancer
Current Medicinal Chemistry Kynurenine System and Multiple Sclerosis, Pathomechanism and Drug Targets with An Emphasis on Laquinimod
Current Drug Targets Crystallization and Preliminary X-Ray Studies of the Fab Fragment from a Humanized Version of the Mouse Anti-Human Fas Antibody Hfe7a
Protein & Peptide Letters Animal Models of Central Nervous System Immune-Mediated Diseases: Therapeutic Interventions with Bioactive Peptides and Mimetics
Current Medicinal Chemistry Potential Use of Drugs that Target Neural-Immune Pathways in the Treatment of Rheumatoid Arthritis and Other Autoimmune Diseases
Current Drug Targets - Inflammation & Allergy Modulation of Inducible Nitric Oxide Synthase Activation by Immuno-suppressive Drugs
Current Drug Metabolism S1P Receptor Modulators in Cell Trafficking and Therapeutics
Current Immunology Reviews (Discontinued) Computational Studies Applied to Anti-inflammatory Drug Discovery: A Review
Current Organic Chemistry Catecholamines: Physiological Immunomodulators During Health and Illness
Current Medicinal Chemistry Pharmacological Intervention at CCR1 and CCR5 as an Approach for Cancer: Help or Hindrance
Current Topics in Medicinal Chemistry The Relationship Between Social Support, Social Constraint, and Psychological Adjustment for Patients with Rare Autoimmune Disease
Current Rheumatology Reviews Regulation of Ocular Immune Responses by Corneal Epithelium
Current Immunology Reviews (Discontinued) B-Cell Based Gene Therapy for Autoimmune Diseases
Infectious Disorders - Drug Targets Oral Contraceptives and Autoimmune Diseases
Current Women`s Health Reviews Cannabinoids, Immune System and Cytokine Network
Current Pharmaceutical Design Immuno - Functionalized Silver Nanoparticles for Diagnostics, Therapeutics and Protection of Rabies Viral Infection
Current Nanomedicine Modifying TNF alpha for Therapeutic Use A Perspective on the TNF Receptor System
Mini-Reviews in Medicinal Chemistry Natural and Induced Regulatory T Cells: Targets for Immunotherapy of Autoimmune Disease and Allergy
Inflammation & Allergy - Drug Targets (Discontinued) Dietary N-3 Fatty Acids and Calorie Restriction in Autoimmune Disease:Influence in Different Immune Compartments
Current Organic Chemistry A Neutralization scFv Antibody against IL-1β Isolated from a NIPA-based Bacterial Display Library
Current Pharmaceutical Biotechnology