Abstract
A series of N,N-Bis(2-hydroxylbenzyl)-1,2-ethanediamine derivatives and its schiff bases were synthesized, characterized and screened for in vitro antimicrobial activity against Staphylococcus aureus, Pseudomonas aeruginosa and Salmonella enterica. Result indicated that the ethylenediamine derivatives, N,N-Bis(2-hydroxy-5-bromobenzyl)-1,2- ethanediamine (21), and N,N-Bis(2-hydroxy-5-chlorobenzyl)-1,2-ethanediamine (22) showed the most favorable antimicrobial activity exhibiting LC50 of 11.6 and 8.79 μM against S.enterica, 86 and 138 μM against P. aeruginosa, and 140 and 287 μM against S. aureus, respectively. These compounds displayed highest level of resistance with S. aureus. Thus, the high level of activity seen with the compounds (21, 22) suggests that these compounds could serve as the leads for development of novel synthetic compounds with enhanced antimicrobial activity.
Keywords: Schiff base, N, N-ethylenediamine, Antimicrobial activity
Letters in Drug Design & Discovery
Title: Synthesis and Antimicrobial Activity of N,N-Bis(2-hydroxylbenzyl)-1,2- ethanediamine Derivatives
Volume: 7 Issue: 3
Author(s): Musiliyu A. Musa, M. Omar F. Khan, Arden Aspedon and John S. Cooperwood
Affiliation:
Keywords: Schiff base, N, N-ethylenediamine, Antimicrobial activity
Abstract: A series of N,N-Bis(2-hydroxylbenzyl)-1,2-ethanediamine derivatives and its schiff bases were synthesized, characterized and screened for in vitro antimicrobial activity against Staphylococcus aureus, Pseudomonas aeruginosa and Salmonella enterica. Result indicated that the ethylenediamine derivatives, N,N-Bis(2-hydroxy-5-bromobenzyl)-1,2- ethanediamine (21), and N,N-Bis(2-hydroxy-5-chlorobenzyl)-1,2-ethanediamine (22) showed the most favorable antimicrobial activity exhibiting LC50 of 11.6 and 8.79 μM against S.enterica, 86 and 138 μM against P. aeruginosa, and 140 and 287 μM against S. aureus, respectively. These compounds displayed highest level of resistance with S. aureus. Thus, the high level of activity seen with the compounds (21, 22) suggests that these compounds could serve as the leads for development of novel synthetic compounds with enhanced antimicrobial activity.
Export Options
About this article
Cite this article as:
Musa A. Musiliyu, F. Khan Omar M., Aspedon Arden and Cooperwood S. John, Synthesis and Antimicrobial Activity of N,N-Bis(2-hydroxylbenzyl)-1,2- ethanediamine Derivatives, Letters in Drug Design & Discovery 2010; 7 (3) . https://dx.doi.org/10.2174/157018010790596678
DOI https://dx.doi.org/10.2174/157018010790596678 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Rapid and Convenient CuCl2 Catalysed Microwave-Assisted Synthesis of Novel Spiro [indoline-3,4'-quinoline] Derivatives
Current Microwave Chemistry AIDS-Defining Illnesses: A Comparison Between Before and After Commencement of Highly Active Antiretroviral Therapy (HAART)
Current HIV Research Sunlight Vitamin D and Skin Cancer
Anti-Cancer Agents in Medicinal Chemistry Meet Our Editorial Board Member
Current Bioinformatics Rediscovery of Halogen Bonds in Protein-Ligand Complexes
Mini-Reviews in Medicinal Chemistry High Throughput Mutation Screening by Automated Capillary Electrophoresis
Combinatorial Chemistry & High Throughput Screening Exploring and Exploiting Biologically Relevant Chemical Space
Current Drug Targets Targeting Tumor Necrosis Factor-α in the Therapy of Psoriasis
Current Drug Targets - Inflammation & Allergy Editorial [Towards an Ecology of Collective Innovation: Human Variome Project (HVP), Rare Disease Consortium for Autosomal Loci (RaDiCAL) and Data-Enabled Life Sciences Alliance (DELSA)]
Current Pharmacogenomics and Personalized Medicine Host-Cell Survival and Death During Chlamydia Infection
Current Immunology Reviews (Discontinued) Polymer Based Drug Delivery Systems for Mycobacterial Infections
Current Drug Delivery Deciphering the Antimicrobial Activity of Phenanthroline Chelators
Current Medicinal Chemistry Synthesis, Antitrypanosomal and Antimycobacterial Activities of Coumarin N-acylhydrazonic Derivatives
Medicinal Chemistry The Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Infectious Disorders - Drug Targets Inflammatory Caspases: Targets for Novel Therapies
Current Pharmaceutical Design Biologic Therapy in Inflammatory and Immunomediated Arthritis: Safety Profile
Current Drug Safety The Role of Oxazolidine Derivatives in the Treatment of Infectious and Chronic Diseases
Current Bioactive Compounds Recent Applications of Birch Reduction in Total Synthesis of Natural Products
Current Organic Chemistry Editorial
Current Molecular Medicine Dicoumarol: A Drug which Hits at Least Two Very Different Targets in Vitamin K Metabolism
Current Drug Targets