Abstract
CXCR4 is the receptor for a chemokine, CXCL12 (stromal cell-derived factor-1, SDF-1). The CXCL12- CXCR4 axis has been proven to be involved in several problematic diseases, including AIDS, cancer cell metastasis, leukemia cell progression and rheumatoid arthritis (RA). Thus, CXCR4 is thought to be an important therapeutic target to overcome the above diseases. We have developed several specific CXCR4 antagonists.
Keywords: Leukemia cell progression, cancer metastasis, chemokine receptor, HIV infection, low molecular weight CXCR4 antagonist, rheumatoid arthritis, T140, T22
Mini-Reviews in Medicinal Chemistry
Title: The Chemokine Receptor CXCR4 as a Therapeutic Target for Several Diseases
Volume: 6 Issue: 9
Author(s): Hirokazu Tamamura, Hiroshi Tsutsumi and Nobutaka Fujii
Affiliation:
Keywords: Leukemia cell progression, cancer metastasis, chemokine receptor, HIV infection, low molecular weight CXCR4 antagonist, rheumatoid arthritis, T140, T22
Abstract: CXCR4 is the receptor for a chemokine, CXCL12 (stromal cell-derived factor-1, SDF-1). The CXCL12- CXCR4 axis has been proven to be involved in several problematic diseases, including AIDS, cancer cell metastasis, leukemia cell progression and rheumatoid arthritis (RA). Thus, CXCR4 is thought to be an important therapeutic target to overcome the above diseases. We have developed several specific CXCR4 antagonists.
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Cite this article as:
Tamamura Hirokazu, Tsutsumi Hiroshi and Fujii Nobutaka, The Chemokine Receptor CXCR4 as a Therapeutic Target for Several Diseases, Mini-Reviews in Medicinal Chemistry 2006; 6 (9) . https://dx.doi.org/10.2174/138955706778195135
DOI https://dx.doi.org/10.2174/138955706778195135 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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