Abstract
Mycobacterium w is a non-pathogenic, saprophytic, atypical mycobacterium with the ability to produce macrophage activating factors from lymphocytes of human patients. Prior immunization with heat-killed suspension of Mycobacterium w shows protection against sub-lethal infection with Mycobacterium tuberculosis H37Rv in mice. Heatkilled Mycobacterium w vaccine is manufactured by M/s Cadila Pharmaceuticals, Ahmedabad, India. Combined heatkilled M. w vaccine and multidrug treatment (MDT) revealed clinical, histological and bacteriological improvements in highly bacillated untreated anergic lepromatous cases of leprosy. In healthy contacts of leprosy patients, M. w vaccine has shown lepromin conversion and protection against leprosy. Only a few clinical studies have been carried out using antituberculous treatment with and without M. w vaccine in pulmonary tuberculosis, in which faster sputum conversion and higher cure rate have been observed in M. w group. M. w vaccine has shown potential of Tuberculin conversion in HIV positive subjects. In a study, five monthly doses of M. w vaccine have shown highly significant increase in CD4 count in HIV positive human beings. More clinical trials are needed to confirm beneficial role of M. w vaccine as an immunomodulator in therapy and prevention of tuberculosis, particularly so in multidrug resistant tuberculosis and those with HIV infection.
Keywords: Mycobacterium w, immunomodulator, tuberculosis, leprosy, immunoprophylaxis, immunotherapy
Current Respiratory Medicine Reviews
Title: Potential Utility of Mycobacterium w Vaccine in Control of Tuberculosis
Volume: 2 Issue: 2
Author(s): Murli L. Mathur
Affiliation:
Keywords: Mycobacterium w, immunomodulator, tuberculosis, leprosy, immunoprophylaxis, immunotherapy
Abstract: Mycobacterium w is a non-pathogenic, saprophytic, atypical mycobacterium with the ability to produce macrophage activating factors from lymphocytes of human patients. Prior immunization with heat-killed suspension of Mycobacterium w shows protection against sub-lethal infection with Mycobacterium tuberculosis H37Rv in mice. Heatkilled Mycobacterium w vaccine is manufactured by M/s Cadila Pharmaceuticals, Ahmedabad, India. Combined heatkilled M. w vaccine and multidrug treatment (MDT) revealed clinical, histological and bacteriological improvements in highly bacillated untreated anergic lepromatous cases of leprosy. In healthy contacts of leprosy patients, M. w vaccine has shown lepromin conversion and protection against leprosy. Only a few clinical studies have been carried out using antituberculous treatment with and without M. w vaccine in pulmonary tuberculosis, in which faster sputum conversion and higher cure rate have been observed in M. w group. M. w vaccine has shown potential of Tuberculin conversion in HIV positive subjects. In a study, five monthly doses of M. w vaccine have shown highly significant increase in CD4 count in HIV positive human beings. More clinical trials are needed to confirm beneficial role of M. w vaccine as an immunomodulator in therapy and prevention of tuberculosis, particularly so in multidrug resistant tuberculosis and those with HIV infection.
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Cite this article as:
Mathur L. Murli, Potential Utility of Mycobacterium w Vaccine in Control of Tuberculosis, Current Respiratory Medicine Reviews 2006; 2 (2) . https://dx.doi.org/10.2174/157339806776843120
DOI https://dx.doi.org/10.2174/157339806776843120 |
Print ISSN 1573-398X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6387 |
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