A Brief Review of circRNA Biogenesis, Detection, and Function

Title:A Brief Review of circRNA Biogenesis, Detection, and Function

Volume: 22 Issue: 7

Author(s): Ying Liang*, Niannian Liu, Le Yang, Jianjun Tang, Yinglong Wang*Meng Mei

Affiliation:

• College of Computer and Information Engineering, Jiangxi Agricultural University, Nanchang,China

• College of Computer and Information Engineering, Jiangxi Agricultural University, Nanchang,China

Keywords: CircRNA, alternative splicing, miRNA sponge, complementary intron, biomarker, disease.

Abstract: Circular RNA (circRNA) is a non-coding molecule produced through alternative splicing of one or more exons of a gene in the presence of an RNA-induced silencing complex (RISC). Its formation depends on complementary intron sequences on both sides of the circularized sequence. CircRNA functions as a sponge for miRNA, playing the role of the transcriptional regulator or potential biomarker. It has an impact on fetal growth and on synaptic facilitation in the brain. In this review, we illustrate biogenesis mechanisms, characteristics, and functions of cirRNAs. We also summarize methods using sequence feature and RNA next-generation sequencing data for circRNA prediction. Finally, we discuss the state of the research on circRNA in diseases, which will bring new contributions to future disease treatments.

Cite this article as:

Liang Ying *, Liu Niannian , Yang Le , Tang Jianjun , Wang Yinglong *, Mei Meng , A Brief Review of circRNA Biogenesis, Detection, and Function, Current Genomics 2021; 22 (7) . https://dx.doi.org/10.2174/1389202922666210331130722