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Current Molecular Pharmacology

Editor-in-Chief

ISSN (Print): 1874-4672
ISSN (Online): 1874-4702

Review Article

Minocycline and Doxycycline: More Than Antibiotics

Author(s): Sher Singh, Deepa Khanna* and Sanjeev Kalra

Volume 14, Issue 6, 2021

Published on: 10 February, 2021

Article ID: e301221191269 Pages: 20

DOI: 10.2174/1874467214666210210122628

Price: $65

Abstract

Minocycline and doxycycline both are second-generation tetracycline antibiotics with similar chemical structures and comparable antibacterial spectrum. Minocycline has also emerged as the tetracycline of choice for multidrug-resistant Acinetobacter baumannii infections, although doxycycline has also shown the activity. Minocycline showed promising results in experimental neurology, which was due to its highly lipophilic nature. It is clinically safe and effective adjunct to antipsychotic medications. The objective of the current review is to provide clinical and preclinical, non-antibiotic uses of minocycline as well as doxycycline. Relevant literature covers antibiotic actions but is more specifically concerned with the non-antibiotic biological aspect of tetracyclines. Non-antibiotic biological effects for both the antibiotics were identified through searching relevant databases including: PubMed, Scopus, and Web of Science up to 2020, using the keywords ‘minocycline and doxycycline’. Anti-inflammatory, anti-oxidant, anti-apoptotic neuroprotective, immunomodulatory and the number of other non-antibiotic effects were compiled for minocycline and doxycycline.

Keywords: Minocycline, doxycycline, antibacterial, neuroprotective, anti-cancer, anti-inflammatory.

Graphical Abstract

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