Abstract
A search for susceptibility genes for psychiatric illness may benefit from recent advances in mouse molecular genetics. Molecular and phenotypic characterization of single gene mutations in mice with anomalies in neurophysiological or neurodevelopmental processes, disrupted in a psychiatric disease, can reveal new insights into the pathways that underlie these genetically complex illnesses. However, in the case of many psychiatric disorders such as autism and schizophrenia, the exact nature of these neurophysiological or neurodevelopmental processes is not known. For example, nothing is known about the molecular pathology underlying impaired social behavior, a prominent feature of both autism and schizophrenia. In this review we discuss published reports on genetic and pharmacological studies of social behavior in mice. We argue that paradigms for studies of the genetics and neurobiological origins of social interactions in mice are amenable to gene- and phenotype-based mutagenesis screens and that identification of a core set of genes that underlie social behavior in mice may provide important clues for our understanding of some aspects of autism and schizophrenia.
Keywords: endophenotype, psychiatric, neurodevelopmental, autism, schizophrenia
Current Genomics
Title: Social Behavior as an Endophenotype for Psychiatric Disorders Development of Mouse Models
Volume: 2 Issue: 1
Author(s): Dubravka Hranilovic and Maja Bucan
Affiliation:
Keywords: endophenotype, psychiatric, neurodevelopmental, autism, schizophrenia
Abstract: A search for susceptibility genes for psychiatric illness may benefit from recent advances in mouse molecular genetics. Molecular and phenotypic characterization of single gene mutations in mice with anomalies in neurophysiological or neurodevelopmental processes, disrupted in a psychiatric disease, can reveal new insights into the pathways that underlie these genetically complex illnesses. However, in the case of many psychiatric disorders such as autism and schizophrenia, the exact nature of these neurophysiological or neurodevelopmental processes is not known. For example, nothing is known about the molecular pathology underlying impaired social behavior, a prominent feature of both autism and schizophrenia. In this review we discuss published reports on genetic and pharmacological studies of social behavior in mice. We argue that paradigms for studies of the genetics and neurobiological origins of social interactions in mice are amenable to gene- and phenotype-based mutagenesis screens and that identification of a core set of genes that underlie social behavior in mice may provide important clues for our understanding of some aspects of autism and schizophrenia.
Export Options
About this article
Cite this article as:
Hranilovic Dubravka and Bucan Maja, Social Behavior as an Endophenotype for Psychiatric Disorders Development of Mouse Models, Current Genomics 2001; 2 (1) . https://dx.doi.org/10.2174/1389202013351138
DOI https://dx.doi.org/10.2174/1389202013351138 |
Print ISSN 1389-2029 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5488 |
Call for Papers in Thematic Issues
Advanced Computational Algorithms and Artificial Intelligence in Clinical Pharmacogenomics
In the era of personalized medicine, understanding the relationship between genetics and drug response is crucial. This issue delves into innovative methodologies, leveraging deep computational analysis and artificial intelligence, to enhance the field of Clinical Pharmacogenomics. The interdisciplinary approach harnesses the power of advanced high-throughput genotyping technologies, sophisticated computational analysis, ...read more
Applications of Single-cell Sequencing Technology in Reproductive Medicine
Single cell sequencing (SCS) technology utilizes individual cells' genetic material to sequence their genome, transcriptome, and epigenetics at the molecular level. It offers insights into cell heterogeneity and enables the study of limited biological materials. Since its recognition as a valuable technique in 2011, single cell sequencing has yielded numerous ...read more
Big Data in Cancer Research
Cancer is a significant threat to human life and health, remaining a highly aggressive killer. It is a leading cause of death worldwide and represents a crucial medical issue for humanity. However, in the past decade, the effectiveness of new synthetic anticancer agents has not matched the current clinical speculation. ...read more
Current Genomics in Cardiovascular Research
Cardiovascular diseases are the main cause of death in the world, in recent years we have had important advances in the interaction between cardiovascular disease and genomics. In this Research Topic, we intend for researchers to present their results with a focus on basic, translational and clinical investigations associated with ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Barbiturates: A Review of Synthesis and Antimicrobial Research Progress
Current Organic Synthesis Na+ Channel Pharmacology and Molecular Mechanisms of Gating
Current Pharmaceutical Design Optimized Feature Selection for Enhanced Epileptic Seizure Detection
Current Medical Imaging Bryostatin-1 Synergizes with Histone Deacetylase Inhibitors to Reactivate HIV-1 from Latency
Current HIV Research Targeting MAPK Signalling: Prometheus Fire or Pandoras Box?
Current Pharmaceutical Design Anti-Inflammatory Immunotherapy for Multiple Sclerosis/Experimental Autoimmune Encephalomyelitis (EAE) Disease
Current Medicinal Chemistry A Comparative Study of the CYP450 Inhibition Potential of Marketed Drugs Using Two Fluorescence Based Assay Platforms Routinely Used in the Pharmaceutical Industry
Drug Metabolism Letters An Update on GABA Analogs for CNS Drug Discovery
Recent Patents on CNS Drug Discovery (Discontinued) CAR, The Continuously Advancing Receptor, in Drug Metabolism and Disease
Current Drug Metabolism Pharmacological Investigation and Unraveling Mechanism of Action of Jasminum sambac Flowers for Predicated Treatment of Alzheimer’s Disease
Current Nutrition & Food Science Pharmacokinetics of Topical Ocular Drug Delivery: Potential Uses for the Treatment of Diseases of the Posterior Segment and Beyond
Current Drug Metabolism Commentary: Recalling Memory by Brain Stimulation
CNS & Neurological Disorders - Drug Targets Folate Status and Depressive Symptoms in Reproductive-Age Women
Current Nutrition & Food Science Adaptive Behavior in Williams-Beuren Syndrome, Down Syndrome, and Autism Spectrum Disorder
Current Psychiatry Reviews Digitoxin Suppresses Store Operated Calcium Entry by Modulating Phosphorylation and the Pore Region of Orai1
Current Molecular Medicine In Silico Approaches Towards the Understanding of the Structure- Function Relationships in Metabotropic Glutamate Receptors (mGluRs) and other Family C GPRCs
Current Pharmaceutical Design Narcolepsy in Adolescents: A Review and Three Case Reports
Adolescent Psychiatry Coenzyme Q10 and Neurological Diseases: An Update
Letters in Drug Design & Discovery Polymer-Based Drug Delivery Devices for Neurological Disorders
CNS & Neurological Disorders - Drug Targets Human Microdialysis
Current Pharmaceutical Biotechnology