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Letters in Drug Design & Discovery

Editor-in-Chief

ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

Synthesis and Biological Evaluation of a Range of Thiosemicarbazone - Based Compounds as Potential Inhibitors of Estrone Sulfatase (ES)

Author(s): Amit Kumar, Sukriti Singh, Hadi Bordbar, Timothy Cartledge and Sabbir Ahmed

Volume 8, Issue 3, 2011

Page: [241 - 245] Pages: 5

DOI: 10.2174/157018011794578231

Price: $65

Abstract

We report the initial results of our study into a series of thiosemicarbazone-based compounds as potential inhibitors of estrone sulfatase (ES). The results show the compounds to be weak inhibitors of ES in comparison to the standard estrone-3-O-sulfamate used within the study and which possessed 98% inhibition under similar conditions.

Keywords: Estrone sulfatase, Inhibition, Breast cancer, Thiosemicarbazones, Non-steroidal, Non-competitive inhibition


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