Abstract
Suramin is a polysulfonated polyaromatic symmetrical urea. It is currently used to treat African river blindness and African sleeping sickness. Suramin has also been extensively trialed recently to treat a number of other diseases, including many cancers. Here, we examine its modes of action and discuss its structure-activity relationships.
Keywords: Suramin, trypanosomiasis, onchocerciasis, FGF
Mini-Reviews in Medicinal Chemistry
Title: Suramin: Clinical Uses and Structure-Activity Relationships
Volume: 8 Issue: 13
Author(s): Ross P. McGeary, Andrew J. Bennett, Quoc B. Tran, Kelly L. Cosgrove and Benjamin P. Ross
Affiliation:
Keywords: Suramin, trypanosomiasis, onchocerciasis, FGF
Abstract: Suramin is a polysulfonated polyaromatic symmetrical urea. It is currently used to treat African river blindness and African sleeping sickness. Suramin has also been extensively trialed recently to treat a number of other diseases, including many cancers. Here, we examine its modes of action and discuss its structure-activity relationships.
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Cite this article as:
McGeary P. Ross, Bennett J. Andrew, Tran B. Quoc, Cosgrove L. Kelly and Ross P. Benjamin, Suramin: Clinical Uses and Structure-Activity Relationships, Mini-Reviews in Medicinal Chemistry 2008; 8 (13) . https://dx.doi.org/10.2174/138955708786369573
DOI https://dx.doi.org/10.2174/138955708786369573 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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