Genomic Organization and Control of the Grb7 Gene Family

E.      Lucas-Fernandez; I.      Garcia-Palmero; A.      Villalobo

Abstract

Grb7 and their related family members Grb10 and Grb14 are adaptor proteins, which participate in the functionality of multiple signal transduction pathways under the control of a variety of activated tyrosine kinase receptors and other tyrosine-phosphorylated proteins. They are involved in the modulation of important cellular and organismal functions such as cell migration, cell proliferation, apoptosis, gene expression, protein degradation, protein phosphorylation, angiogenesis, embryonic development and metabolic control. In this short review we shall describe the organization of the genes encoding the Grb7 protein family, their transcriptional products and the regulatory mechanisms implicated in the control of their expression. Finally, the alterations found in these genes and the mechanisms affecting their expression under pathological conditions such as cancer, diabetes and some congenital disorders will be highlighted.

Keywords: Adaptor proteins, cancer, congenital disorders, diabetes, genetic imprinting, Grb7, Grb10, Grb14, uniparental disomy, splice variants