Abstract
Common (surface) epithelial cancer of the ovary is epitomized by metastasis to organs of the abdominal cavity. Proteolytic enzymes, predominately those of the matrix metalloproteinase and plasminogen activator-plasmin systems, have been implicated as mediators of tissue invasion. This review highlights the salient features of ovarian cancer progression, the proteases involved, and experimental approaches of inhibition. Enzyme inhibitors hold promise in the treatment of early-stage and recurrent (following cytoreductive surgery) disease.
Keywords: matrix metalloproteinase, urokinase, kallikrein, ovarian cancer, protease inhibitor
Current Enzyme Inhibition
Title: Proteolytic Enzymes and Their Inhibition in Epithelial Ovarian Cancer
Volume: 1 Issue: 2
Author(s): A. McDonnel Smedts, T. E. Curry Jr. and W. J. Murdoch
Affiliation:
Keywords: matrix metalloproteinase, urokinase, kallikrein, ovarian cancer, protease inhibitor
Abstract: Common (surface) epithelial cancer of the ovary is epitomized by metastasis to organs of the abdominal cavity. Proteolytic enzymes, predominately those of the matrix metalloproteinase and plasminogen activator-plasmin systems, have been implicated as mediators of tissue invasion. This review highlights the salient features of ovarian cancer progression, the proteases involved, and experimental approaches of inhibition. Enzyme inhibitors hold promise in the treatment of early-stage and recurrent (following cytoreductive surgery) disease.
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Cite this article as:
Smedts McDonnel A., Curry Jr. E. T. and Murdoch J. W., Proteolytic Enzymes and Their Inhibition in Epithelial Ovarian Cancer, Current Enzyme Inhibition 2005; 1 (2) . https://dx.doi.org/10.2174/1573408054022199
DOI https://dx.doi.org/10.2174/1573408054022199 |
Print ISSN 1573-4080 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6662 |
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