Abstract
Sepsis is a complex disease and coagulation derangements are part of this context. The inflammatory storm is ultimately responsible for coagulation derangements. It is characterized by exacerbated coagulation, impaired anticoagulation and decreased fibrin removal. These derangements are implicated in the generation of microcirculation thrombosis, with deposition of microclots and obstruction of circulation, impairing blood flow and contributing to tissue hypoperfusion and consequently, organ dysfunction. This review will address the main issues regarding coagulation disorders in the context of sepsis.
Keywords: Sepsis, coagulation, fibrinolysis, activated protein C, antithrombin, tissue factor
Endocrine, Metabolic & Immune Disorders - Drug Targets
Title: Coagulation and Sepsis
Volume: 6 Issue: 2
Author(s): F. R. Machado and E. Silva
Affiliation:
Keywords: Sepsis, coagulation, fibrinolysis, activated protein C, antithrombin, tissue factor
Abstract: Sepsis is a complex disease and coagulation derangements are part of this context. The inflammatory storm is ultimately responsible for coagulation derangements. It is characterized by exacerbated coagulation, impaired anticoagulation and decreased fibrin removal. These derangements are implicated in the generation of microcirculation thrombosis, with deposition of microclots and obstruction of circulation, impairing blood flow and contributing to tissue hypoperfusion and consequently, organ dysfunction. This review will address the main issues regarding coagulation disorders in the context of sepsis.
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Cite this article as:
Machado R. F. and Silva E., Coagulation and Sepsis, Endocrine, Metabolic & Immune Disorders - Drug Targets 2006; 6 (2) . https://dx.doi.org/10.2174/187153006777442369
DOI https://dx.doi.org/10.2174/187153006777442369 |
Print ISSN 1871-5303 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3873 |
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