Abstract
With advances in diagnosis and treatment, breast cancer has become an increasingly survivable disease with a growing population of long-term survivors. As an essential component of breast conservation therapy, radiotherapy is a standard treatment for many women with stage I/II breast cancer. Cardiac radiation exposure has been associated with an increased risk of cardiovascular diseases. Among these are coronary artery disease, cardiomyopathy, valvular heart disease, and pericardial disease. Microvascular changes and accelerated atherosclerosis are likely the primary underlying mechanisms of radiation induced cardiovascular damage. A simple and highly effective technique, deep inspiration breath-hold (DIBH), has been shown to decrease cardiac radiation exposure without compromising target coverage. This brief review focuses on the effects of radiation therapy on the heart, radiation-induced cardiovascular diseases in breast cancer survivors, and the DIBH technique as a means for reducing cardiac radiation exposure.
Keywords: Breast cancer, cardiotoxicity, cardiovascular diseases, DIBH, fibrosis, radiotherapy.
Current Cancer Therapy Reviews
Title:Deep Inspiration Breath-hold (DIBH) Technique to Reduce Cardiac Radiation Dose in the Management of Breast Cancer
Volume: 12 Issue: 1
Author(s): Mutlay Sayan, William E. Hopkins and Ruth Heimann
Affiliation:
Keywords: Breast cancer, cardiotoxicity, cardiovascular diseases, DIBH, fibrosis, radiotherapy.
Abstract: With advances in diagnosis and treatment, breast cancer has become an increasingly survivable disease with a growing population of long-term survivors. As an essential component of breast conservation therapy, radiotherapy is a standard treatment for many women with stage I/II breast cancer. Cardiac radiation exposure has been associated with an increased risk of cardiovascular diseases. Among these are coronary artery disease, cardiomyopathy, valvular heart disease, and pericardial disease. Microvascular changes and accelerated atherosclerosis are likely the primary underlying mechanisms of radiation induced cardiovascular damage. A simple and highly effective technique, deep inspiration breath-hold (DIBH), has been shown to decrease cardiac radiation exposure without compromising target coverage. This brief review focuses on the effects of radiation therapy on the heart, radiation-induced cardiovascular diseases in breast cancer survivors, and the DIBH technique as a means for reducing cardiac radiation exposure.
Export Options
About this article
Cite this article as:
Sayan Mutlay, Hopkins E. William and Heimann Ruth, Deep Inspiration Breath-hold (DIBH) Technique to Reduce Cardiac Radiation Dose in the Management of Breast Cancer, Current Cancer Therapy Reviews 2016; 12 (1) . https://dx.doi.org/10.2174/1573394712999160713165810
DOI https://dx.doi.org/10.2174/1573394712999160713165810 |
Print ISSN 1573-3947 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6301 |
Call for Papers in Thematic Issues
Current progress in Protein Degradation and Cancer Therapy
argeted Protein Degradation is gaining momentum in cancer therapy, it facilitate targeting undruggable proteins, it overcome cancer resistance and avoid undesirable side effects. Thus small molecules degraders have emerged as novel therapeutic strategy. Targeted protein degradation (TPD), the process of eliminating a protein of interest hold a great promise for ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Small-molecule Antiviral Agents in Ongoing Clinical Trials for COVID-19
Current Drug Targets Synergy of microRNA and Stem Cell: A Novel Therapeutic Approach for Diabetes Mellitus and Cardiovascular Diseases
Current Diabetes Reviews MicroRNAs: Novel Diagnostic and Prognostic Biomarkers in Atherosclerosis
Current Topics in Medicinal Chemistry New Analytical Tools for Studying Autoimmune Diseases
Current Pharmaceutical Design Obstructive Sleep Apnea and Atrial Arrhythmogenesis
Current Cardiology Reviews Rheumatoid Arthritis: Cardiovascular Manifestations, Pathogenesis, and Therapy
Current Pharmaceutical Design Possible Involvement of TRP Channels in Cardiac Hypertrophy and Arrhythmia
Current Topics in Medicinal Chemistry Green Tea Catechins and Cardiovascular Health: An Update
Current Medicinal Chemistry Targeting Transient Receptor Potential Canonical Channels for Diseases of the Nervous System
Current Drug Targets Current Perspectives on Anti-Aging Interventions
Letters in Drug Design & Discovery Respiratory Gas Exchange During Exercise in Children with Congenital Heart Disease: Methodology and Clinical Concepts
Current Respiratory Medicine Reviews The Therapeutic Potential of Hepatocyte Growth Factor for Myocardial Infarction and Heart Failure
Current Pharmaceutical Design Methods for Identifying Cardiovascular Agents: A Review
Recent Patents on Cardiovascular Drug Discovery Nongenomic Actions of Thyroid Hormones: From Basic Research to Clinical Applications. An Update
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued) Multiple Drug Resistance Associated with Function of ABC-Transporters in Diabetes Mellitus: Molecular Mechanism and Clinical Relevance
Infectious Disorders - Drug Targets Expression of microRNAs (133b and 138) and Correlation with Echocardiographic Parameters in Patients with Alcoholic Cardiomyopathy
MicroRNA Electroconvulsive Therapy in Child and Adolescent Psychiatry
Current Psychiatry Reviews Gender Related Issues in the Management of Heart Failure
Current Pharmaceutical Design Recent Progress and Related Patents on the Applications of Bone Marrow-Derived Stem/Progenitor Cells in Regenerative Medicine and Cancer Therapies
Recent Patents on Regenerative Medicine A Brief History of ‘Lone’ Atrial Fibrillation: From ‘A Peculiar Pulse Irregularity’ to a Modern Public Health Concern
Current Pharmaceutical Design