Abstract
We report a case of isoniazid induced convulsions in 35 years old male alcoholic and smoker patient receiving intensive phase therapy for pulmonary tuberculosis. A case was confirmed by accidental positive de-challenge and rechallenge as well as ruled out other conditions. Use of isoniazid in alcoholic and smoker patient required a caution for prevention of neurological adverse reactions. Pyridoxine should always be prescribed to such patients for the prevention of such adverse reaction.
Keywords: Adverse drug reaction, alcohol, convulsions, isoniazid, pyridoxine deficiency, smoking.
Current Drug Safety
Title:Isoniazid Induced Convulsions at Therapeutic Dose in an Alcoholic and Smoker Patient
Volume: 10 Issue: 1
Author(s): Amol S. Aiwale, Utkarsh A. Patel, Manish J. Barvaliya, Pramod R. Jha and Chandrabhanu Tripathi
Affiliation:
Keywords: Adverse drug reaction, alcohol, convulsions, isoniazid, pyridoxine deficiency, smoking.
Abstract: We report a case of isoniazid induced convulsions in 35 years old male alcoholic and smoker patient receiving intensive phase therapy for pulmonary tuberculosis. A case was confirmed by accidental positive de-challenge and rechallenge as well as ruled out other conditions. Use of isoniazid in alcoholic and smoker patient required a caution for prevention of neurological adverse reactions. Pyridoxine should always be prescribed to such patients for the prevention of such adverse reaction.
Export Options
About this article
Cite this article as:
Aiwale S. Amol, Patel A. Utkarsh, Barvaliya J. Manish, Jha R. Pramod and Tripathi Chandrabhanu, Isoniazid Induced Convulsions at Therapeutic Dose in an Alcoholic and Smoker Patient, Current Drug Safety 2015; 10 (1) . https://dx.doi.org/10.2174/1574886309666140930151343
DOI https://dx.doi.org/10.2174/1574886309666140930151343 |
Print ISSN 1574-8863 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3911 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Polymer-based Nanodevices for Effective Antimicrobial Therapy: Synthetic Strategies and Applications
Current Applied Polymer Science Current Management of Alcoholic Liver Disease
Current Drug Abuse Reviews Pentraxins and Atherosclerosis: The Role of PTX3
Current Pharmaceutical Design New Prospects for Nelfinavir in Non-HIV-Related Diseases
Current Molecular Pharmacology A Review on Nuclear Imaging as a Promising Modality for Efficient Diagnosis of Tuberculosis
Current Medical Imaging Current Insights into the Chemistry and Antitubercular Potential of Benzimidazole and Imidazole Derivatives
Mini-Reviews in Medicinal Chemistry Computational Overview of Mycobacterial Thymidine Monophosphate Kinase
Current Pharmaceutical Design Current Therapeutic Approaches in Inflammatory Bowel Disease
Current Pharmaceutical Design Estimation of Affinity of HLA-A*0201 Restricted CTL Epitope Based on the SCORE Function
Protein & Peptide Letters Understanding Mass Spectrometry-based Global Mycobacterial Lipidomics
Current Molecular Medicine Mycobacterium tuberculosis and Dendritic Cells: Whos Manipulating Whom?
Current Immunology Reviews (Discontinued) Drug Repurposing: An Emerging Tool for Drug Reuse, Recycling and Discovery
Current Drug Research Reviews The Co-agonist Site of NMDA-glutamate Receptors: A Novel Therapeutic Target for Age-related Cognitive Decline
Current Pharmaceutical Design Pharmacokinetic and Pharmacodynamic Variability: A Daunting Challenge in Drug Therapy
Current Drug Metabolism Editorial [Hot Topic: New Drug Targets for the Treatment of Asthma (Guest Editor: D. Knight)]
Current Drug Targets Adherence to Antiretroviral Therapy and Tuberculosis Treatment in a Prison of Tehran, Iran
Infectious Disorders - Drug Targets Novel Carriers for Coenzyme Q10 Delivery
Current Drug Delivery The Impact of Crystallographic Data for the Development of Machine Learning Models to Predict Protein-Ligand Binding Affinity
Current Medicinal Chemistry Meet Our Editor:
Current Enzyme Inhibition Bioactive Albumin-Based Carriers for Tumour Chemotherapy
Current Cancer Drug Targets