Journal: Anti-Cancer Agents in Medicinal Chemistry
Guest editor(s):Dr. Giovanni Tossetta
Co-Guest Editor(s):

Introduction

Cancer accounts for nearly 10 million deaths in 2022 and is considered the leading cause of worldwide mortality. Cancer outcome can be improved through an appropriate screening and early detection and through an efficient clinical treatment. Chemotherapy, radiotherapy and surgery are the most important approach for the treatment of several types of cancers. However, intrinsic or acquired resistance and metastasis are still major obstacles to a successful cure. Outstanding progress in genetics and molecular biology provided novel molecular targets and new anticancer agents that could improve the outcome of patients. Moreover, many studies suggested that cotreatment with natural or synthetic compounds can increase the efficiency of chemotherapeutics or reduce/eliminate the side effects of these drugs. It is interesting to note that the beneficial effects of these compounds are mediated by the activation/inhibition of several pathways and enzymes that play a key role in cancer cell growth and proliferation. Moreover, several compounds reached the stage of preclinical and clinical studies suggesting important effects in treatment of several types of cancer. Thus, the research and development of new anticancer agents and therapeutic strategies targeting signaling pathways and enzymes modulation in cancer cells constitutes the main subject of this Special Issue.

Keywords

Chemoresistance, Radioresistance, Cancer, Compounds, Anti-cancer, Cancer progression, Signaling, Modulators

Sub-topics

Ø  Role of natural and synthetic compounds in restoring chemotherapy sensitivity

Ø  Role of natural and synthetic compounds in restoring radiotherapy sensitivity

Ø  Signaling pathway modulation in cancer cell proliferation and invasion

Ø  Enzymatic targets of chemical compounds in cancer cells

Ø  Molecular pathways modulation in cancer cells