Journal: Current Diabetes Reviews
Guest editor(s): Manish Gautam
Co-Guest Editor(s):

Introduction

In recent years, diabetic wounds have become a global health concern with the increase in the incidence of diabetes. Diabetic wounds are a kind of chronic and refractory ulcer. It is generally due to the microcirculatory disturbances and the reduced levels of endogenous growth factors. Delayed cutaneous wound healing is a chronic complication in diabetic patients and is caused primarily by hyperglycemia, oxidative stress, vascular insufficiency and microbial infections. The factors which are responsible for delay the chronic wound healing are Increased infection, Excess formation of free radicals, Persistence of inflammation, Excessive protease activity and reduced collagen formation, Decrease in the production of growth factors such as transforming growth factors (TGF-β), endothelial growth factor (EGF) and vascular endothelial growth factors (VEGF). This special issue endeavors to assemble cutting-edge insights into the mechanisms behind the delayed healing process, which involve increased infection rates, excessive formation of free radicals, persistent inflammation, heightened protease activity, and reduced collagen formation. Furthermore, the aim is to explore therapeutic interventions that target these mechanisms, such as enhancing the production of growth factors. Ultimately, the goal is to develop effective strategies for accelerating wound healing in diabetic patients and improving their quality of life.

Keywords

Diabetic wounds, Chronic ulcer, Microcirculatory disturbances, Endogenous growth factors, Delayed wound healing, Hyperglycemia, Oxidative stress, Therapeutic interventions

Sub-topics

1. Microcirculatory disturbances and reduced endogenous growth factors.
2. Hyperglycemia, oxidative stress, and vascular insufficiency contribute to delayed healing
3. Role of excess formation of free radicals and persistent inflammation.
4. Impact of excessive protease activity and reduced collagen formation on wound healing
5. Novel approaches to enhance the production of growth factors
6. Efficacy of current therapeutic interventions in diabetic wound healing
7. Emerging therapies targeting specific mechanisms implicated in delayed wound healing
8. Potential of bioengineered materials and regenerative medicine approaches in diabetic wound healing
9. Bridging the gap between preclinical research and clinical practice in diabetic wound management
10. Potential challenges and opportunities in translating research findings