Journal: Current Diabetes Reviews
Guest editor(s):Dr. Kota V. Ramana
Co-Guest Editor(s):

Introduction

Diabetes, along with its associated secondary complications, represents a significant global health challenge, contributing significantly to morbidity and mortality. Unhealthy lifestyle habits, reduced physical activity, environmental pollutants, and stress are pivotal factors in the onset of diabetes, particularly type-2 diabetes. Poorly managed hyperglycemia can lead to various complications, including neuropathy, nephropathy, retinopathy, cardiovascular issues, and cataractogenesis. Recent research underscores the impact of heightened reactive oxygen species during hyperglycemia, inducing cellular oxidative stress and disrupting inflammatory responses, thereby contributing to the pathogenesis of diverse diabetic complications. To advance our comprehension of the molecular mechanisms governing oxidative stress and inflammation pathways, a comprehensive exploration is imperative for understanding disease pathology and developing innovative therapeutic approaches. This special issue endeavors to assemble cutting-edge insights into the role of oxidative stress and inflammation in diabetic complications. We invite authors to contribute compelling review articles elucidating the underlying mechanisms of oxidative stress and inflammation in the development of diabetes complications, with the ultimate goal of fostering advancements in the treatment of these complex conditions.

Keywords

Secondary diabetic complications, oxidative stress, inflammation, hyperglycemia, antioxidants, reactive oxygen species.

Sub-topics

- Interplay between oxidative and inflammatory responses in the pathophysiology of diabetic complications.
- Novel anti-oxidative and anti-inflammatory interventions for the therapy diabetic complications.
- Biomarkers of oxidative stress and inflammation in diabetes.
- Recent advances in the treatment of diabetic complications.
- Vitamins and plant products in the prevention of diabetic complications.